ZFAND5 蛋白, Human (Sf9, His, Strep)

The ZFAND5 protein is a key player in protein degradation by the ubiquitin-proteasome system and serves as a potential anchor for ubiquitinated proteins, promoting their proteasomal targeting. It regulates NF-kappa-B activation and apoptosis by inhibiting NF-kappa-B activation induced by various stimuli, including RIPK1 and TRAF6 overexpression. ZFAND5 Protein, Human (Sf9, His, Strep) is the recombinant human-derived ZFAND5 protein, expressed by Sf9 insect cells , with N-Strep, N-8*His labeled tag. The total length of ZFAND5 Protein, Human (Sf9, His, Strep) is 212 a.a., .

ZFAND5 蛋白通过泛素-蛋白酶体系统参与蛋白质降解的复杂过程，可能作为泛素化蛋白的锚点，以促进其靶向蛋白酶体。它的参与延伸到对 NF-kappa-B 激活和细胞凋亡的调节，对各种刺激（包括 RIPK1 和 TRAF6 的过表达）诱导的 NF-kappa-B 激活发挥抑制作用，同时不影响 RELA 触发的激活。ZFAND5 表现出响应 TNF、IL-1 和 TLR4 刺激的 NF-κ-B 激活的剂量依赖性抑制，并使细胞对 TNF 诱导的细胞凋亡敏感。值得注意的是，它是破骨细胞分化的有效抑制因子。在功能上，ZFAND5 与泛素和多泛素化蛋白相互作用，并与泛素和 SQSTM1 形成异源三聚体复合物，其中 ZFAND5 和 SQSTM1 均与相同的泛素分子结合，强调了其在协调泛素介导过程中的作用。此外，ZFAND5 通过特定结构域与 IKBKG、RIPK1 和 TRAF6 相互作用，进一步强调了它参与关键的细胞通路。

Human

Sf9 insect cells

N-Strep;N-8*His

O76080 (A2-I213)

7763

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.