2. Inhibitory Antibodies
  3. Refanezumab

Refanezumab  (Synonyms: 瑞法奈珠单抗; GSK249320)

目录号: HY-P99403

摩尔计算器

Refanezumab (GSK249320) 是一种针对髓鞘相关糖蛋白 (MAG) 的 IgG1 型人源化单克隆抗体。Refanezumab 与 MAG 结合并阻断 MAG 介导的轴突再生抑制。Refanezumab 可以在动物中风模型中穿过血脑屏障 (BBB)。Refanezumab 具有用于增强中风后功能恢复研究的潜力。

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CAS No. : 1233953-61-1

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Refanezumab 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Refanezumab (GSK249320) is an IgG1-type humanized monoclonal antibody directed against myelin-associated glycoprotein (MAG). Refanezumab binds to MAG and blocks MAG-mediated inhibition of axonal regeneration. Refanezumab can cross the blood-brain barrier (BBB) in animal stroke models. Refanezumab has the potential for the enhancement of recovery of function poststroke[1][2].

同型

Human IgG1 kappa
推荐同型对照抗体
种属

Humanized
体内研究
(In Vivo)

Refanezumab (GSK249320; 10 mg/kg; 静脉给药; 在中风后 24 小时开始并每周继续给药 6 次) 显示神经评分和阶梯测试有更大的增加。Refanezumab 通过静脉注射后，可穿透病变部位，并且在中风后 24 小时对功能结果有轻微影响。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague Dawley rats (weight 361g)[1]
Dosage: 10 mg/kg
Administration: IV; starting 24 hours post-stroke and continuing weekly for 6 more doses; starting seven days post-stroke and continuing weekly for 5 more doses
Result: Animals treated 24 hours post-stroke showed larger increases in neuroscore and staircase test as compared to controls, but animals treated 7 days post-stroke showed no significant behavioral benefit.
Clinical Trial
CAS 号
中文名称

瑞法奈珠单抗
储存方式

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Format
  • Human IgG1 kappa
纯度 & 产品资料
参考文献

Refanezumab 相关分类

  • 摩尔计算器

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  • Do most proteins show cross-species activity?

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Keywords:

Refanezumab1233953-61-1GSK249320瑞法奈珠单抗GSK 249320GSK-249320OthersIgG1-typehumanizedmonoclonal antibodymyelin-associated glycoproteinMAGaxonal regenerationblood-brain barrierBBBstrokeInhibitorinhibitorinhibit

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