Rehmannic acid (Synonyms: Lantadene A)

目录号: HY-N1521 纯度: ≥96.0%: FAQs
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Rehmannic acid (lantadene A) 是一种从马缨丹中分离出来的化合物。 Rehmannic acid 以剂量依赖性方式显示出相当大的体外抗氧化、自由基清除能力活性。Rehmannic acid 是一种很有前景的抗氧化剂和保肝剂。

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Rehmannic acid Chemical Structure

CAS No. : 467-81-2

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生物活性
纯度 & 产品资料
参考文献

生物活性

Rehmannic acid (lantadene A) is a compound isolated from Lantana camara. Rehmannic acid shows considerable in vitro antioxidant, free radical scavenging capacity activities in a dose dependant manner. Rehmannic acid is a promising candidate for use as an antioxidant and hepatoprotective agent^[1]^[2].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
786-0	GI₅₀	3.47 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human 786-0 cells by sulforhodamine B assay Growth inhibition of human 786-0 cells by sulforhodamine B assay	[PMID: 23644211]
A498	GI₅₀	2.06 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human A498 cells by sulforhodamine B assay Growth inhibition of human A498 cells by sulforhodamine B assay	[PMID: 23644211]
A549	IC₅₀	1.06 μM Compound: 1, lantadene A	Inhibition of TNFalpha-induced NF-kappaB activation in human A549 cells after 7 hrs by luciferase reporter gene assay Inhibition of TNFalpha-induced NF-kappaB activation in human A549 cells after 7 hrs by luciferase reporter gene assay	[PMID: 25027934]
A549	IC₅₀	1.06 μM Compound: 1, Lantadene A	Inhibition of TNF-alpha-induced NF-kappaB (unknown origin) activation transfected in human A549 cells after 7 hrs by bright-glo luciferase reporter gene assay Inhibition of TNF-alpha-induced NF-kappaB (unknown origin) activation transfected in human A549 cells after 7 hrs by bright-glo luciferase reporter gene assay	[PMID: 24457265]
A549	IC₅₀	2.84 μM Compound: 1, lantadene A	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 25027934]
A549	IC₅₀	2.84 μM Compound: 1, Lantadene A	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 24457265]
A549	GI₅₀	2.84 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human A549/ATCC cells by sulforhodamine B assay Growth inhibition of human A549/ATCC cells by sulforhodamine B assay	[PMID: 23644211]
A549	IC₅₀	21.8 μg/mL Compound: 1	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 18553923]
ACHN	GI₅₀	4.94 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human ACHN cells by sulforhodamine B assay Growth inhibition of human ACHN cells by sulforhodamine B assay	[PMID: 23644211]
BT-549	GI₅₀	4.73 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human BT549 cells by sulforhodamine B assay Growth inhibition of human BT549 cells by sulforhodamine B assay	[PMID: 23644211]
CAKI-1	GI₅₀	3.93 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human CAKI-1 cells by sulforhodamine B assay Growth inhibition of human CAKI-1 cells by sulforhodamine B assay	[PMID: 23644211]
CCRF-CEM	GI₅₀	3.48 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human CCRF-CEM cells by sulforhodamine B assay Growth inhibition of human CCRF-CEM cells by sulforhodamine B assay	[PMID: 23644211]
COLO 205	GI₅₀	2.64 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human COLO205 cells by sulforhodamine B assay Growth inhibition of human COLO205 cells by sulforhodamine B assay	[PMID: 23644211]
DU-145	GI₅₀	5.92 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human DU145 cells by sulforhodamine B assay Growth inhibition of human DU145 cells by sulforhodamine B assay	[PMID: 23644211]
HCC 2998	GI₅₀	3.33 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human HCC2998 cells by sulforhodamine B assay Growth inhibition of human HCC2998 cells by sulforhodamine B assay	[PMID: 23644211]
HCT-116	IC₅₀	13.4 μM Compound: 1	Cytotoxicity against Homo sapiens (human) HCT116 cells assessed as growth inhibition after 48 hr by MTT assay Cytotoxicity against Homo sapiens (human) HCT116 cells assessed as growth inhibition after 48 hr by MTT assay	10.1007/s00044-012-0354-x
HCT-116	GI₅₀	3.62 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human HCT116 cells by sulforhodamine B assay Growth inhibition of human HCT116 cells by sulforhodamine B assay	[PMID: 23644211]
HCT-15	GI₅₀	3.17 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human HCT15 cells by sulforhodamine B assay Growth inhibition of human HCT15 cells by sulforhodamine B assay	[PMID: 23644211]
HeLa	IC₅₀	23.3 μg/mL Compound: 1	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 18553923]
HL-60	IC₅₀	19.3 μM Compound: 1	Cytotoxicity against Homo sapiens (human) HL60 cells assessed as growth inhibition after 48 hr by MTT assay Cytotoxicity against Homo sapiens (human) HL60 cells assessed as growth inhibition after 48 hr by MTT assay	10.1007/s00044-012-0354-x
HL-60	IC₅₀	19.8 μg/mL Compound: 1	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 18553923]
HL-60(TB)	GI₅₀	1.87 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human HL-60(TB) cells by sulforhodamine B assay Growth inhibition of human HL-60(TB) cells by sulforhodamine B assay	[PMID: 23644211]
HOP-62	GI₅₀	2.06 x 10^-5 M Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human HOP62 cells by sulforhodamine B assay Growth inhibition of human HOP62 cells by sulforhodamine B assay	[PMID: 23644211]
HOP-92	GI₅₀	1.19 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human HOP92 cells by sulforhodamine B assay Growth inhibition of human HOP92 cells by sulforhodamine B assay	[PMID: 23644211]
Hs-578T	GI₅₀	5.1 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human Hs 578T cells by sulforhodamine B assay Growth inhibition of human Hs 578T cells by sulforhodamine B assay	[PMID: 23644211]
HSC-2	IC₅₀	50.7 μM Compound: 1	Cytotoxicity against Homo sapiens (human) HSC2 cells assessed as growth inhibition after 48 hr by MTT assay Cytotoxicity against Homo sapiens (human) HSC2 cells assessed as growth inhibition after 48 hr by MTT assay	10.1007/s00044-012-0354-x
HT-29	GI₅₀	4.32 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human HT-29 cells by sulforhodamine B assay Growth inhibition of human HT-29 cells by sulforhodamine B assay	[PMID: 23644211]
IGROV-1	GI₅₀	6.75 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human IGROV1 cells by sulforhodamine B assay Growth inhibition of human IGROV1 cells by sulforhodamine B assay	[PMID: 23644211]
K562	GI₅₀	4.72 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human K562 cells by sulforhodamine B assay Growth inhibition of human K562 cells by sulforhodamine B assay	[PMID: 23644211]
KM12	GI₅₀	3.52 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human KM12 cells by sulforhodamine B assay Growth inhibition of human KM12 cells by sulforhodamine B assay	[PMID: 23644211]
LOX IMVI	GI₅₀	7.8 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human LOXIMVI cells by sulforhodamine B assay Growth inhibition of human LOXIMVI cells by sulforhodamine B assay	[PMID: 23644211]
M14	GI₅₀	4.53 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human M14 cells by sulforhodamine B assay Growth inhibition of human M14 cells by sulforhodamine B assay	[PMID: 23644211]
Malme-3M	GI₅₀	7.91 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human MALME-3M cells by sulforhodamine B assay Growth inhibition of human MALME-3M cells by sulforhodamine B assay	[PMID: 23644211]
MCF7	IC₅₀	25.8 μM Compound: 1	Cytotoxicity against Homo sapiens (human) MCF7 cells assessed as growth inhibition after 48 hr by MTT assay Cytotoxicity against Homo sapiens (human) MCF7 cells assessed as growth inhibition after 48 hr by MTT assay	10.1007/s00044-012-0354-x
MCF7	GI₅₀	3.6 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human MCF7 cells by sulforhodamine B assay Growth inhibition of human MCF7 cells by sulforhodamine B assay	[PMID: 23644211]
MDA-MB-231	GI₅₀	4.53 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human MDA-MB-231 cells by sulforhodamine B assay Growth inhibition of human MDA-MB-231 cells by sulforhodamine B assay	[PMID: 23644211]
MDA-MB-435	GI₅₀	5.24 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human MDA-MB-435 cells by sulforhodamine B assay Growth inhibition of human MDA-MB-435 cells by sulforhodamine B assay	[PMID: 23644211]
MDA-MB-468	GI₅₀	2.58 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human MDA-MB-468 cells by sulforhodamine B assay Growth inhibition of human MDA-MB-468 cells by sulforhodamine B assay	[PMID: 23644211]
MOLT-4	GI₅₀	3.34 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human MOLT4 cells by sulforhodamine B assay Growth inhibition of human MOLT4 cells by sulforhodamine B assay	[PMID: 23644211]
NCI/ADR-RES	GI₅₀	5.12 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human NCI-ADR-RES cells by sulforhodamine B assay Growth inhibition of human NCI-ADR-RES cells by sulforhodamine B assay	[PMID: 23644211]
NCI-H226	GI₅₀	4.71 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human NCI-H226 cells by sulforhodamine B assay Growth inhibition of human NCI-H226 cells by sulforhodamine B assay	[PMID: 23644211]
NCI-H23	GI₅₀	4.55 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human NCI-H23 cells by sulforhodamine B assay Growth inhibition of human NCI-H23 cells by sulforhodamine B assay	[PMID: 23644211]
NCI-H322M	GI₅₀	3.94 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human NCI-H322M cells by sulforhodamine B assay Growth inhibition of human NCI-H322M cells by sulforhodamine B assay	[PMID: 23644211]
NCI-H460	GI₅₀	3.59 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human NCI-H460 cells by sulforhodamine B assay Growth inhibition of human NCI-H460 cells by sulforhodamine B assay	[PMID: 23644211]
NCI-H522	GI₅₀	3.25 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human NCI-H522 cells by sulforhodamine B assay Growth inhibition of human NCI-H522 cells by sulforhodamine B assay	[PMID: 23644211]
OVCAR-3	GI₅₀	5.89 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human OVCAR3 cells by sulforhodamine B assay Growth inhibition of human OVCAR3 cells by sulforhodamine B assay	[PMID: 23644211]
OVCAR-4	GI₅₀	5.64 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human OVCAR4 cells by sulforhodamine B assay Growth inhibition of human OVCAR4 cells by sulforhodamine B assay	[PMID: 23644211]
OVCAR-5	GI₅₀	1.83 x 10^-5 M Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human OVCAR5 cells by sulforhodamine B assay Growth inhibition of human OVCAR5 cells by sulforhodamine B assay	[PMID: 23644211]
OVCAR-8	GI₅₀	4.97 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human OVCAR8 cells by sulforhodamine B assay Growth inhibition of human OVCAR8 cells by sulforhodamine B assay	[PMID: 23644211]
PC-3	GI₅₀	2.53 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human PC3 cells by sulforhodamine B assay Growth inhibition of human PC3 cells by sulforhodamine B assay	[PMID: 23644211]
RPMI-8226	GI₅₀	2 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human RPMI8226 cells by sulforhodamine B assay Growth inhibition of human RPMI8226 cells by sulforhodamine B assay	[PMID: 23644211]
RXF 393	GI₅₀	2.41 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human RXF393 cells by sulforhodamine B assay Growth inhibition of human RXF393 cells by sulforhodamine B assay	[PMID: 23644211]
SF-268	GI₅₀	5.96 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human SF268 cells by sulforhodamine B assay Growth inhibition of human SF268 cells by sulforhodamine B assay	[PMID: 23644211]
SF-295	GI₅₀	2.77 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human SF295 cells by sulforhodamine B assay Growth inhibition of human SF295 cells by sulforhodamine B assay	[PMID: 23644211]
SF-539	GI₅₀	6.51 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human SF539 cells by sulforhodamine B assay Growth inhibition of human SF539 cells by sulforhodamine B assay	[PMID: 23644211]
SK-MEL-2	GI₅₀	3.07 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human SK-MEL-2 cells by sulforhodamine B assay Growth inhibition of human SK-MEL-2 cells by sulforhodamine B assay	[PMID: 23644211]
SK-MEL-28	GI₅₀	1.28 x 10^-5 M Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human SK-MEL-28 cells by sulforhodamine B assay Growth inhibition of human SK-MEL-28 cells by sulforhodamine B assay	[PMID: 23644211]
SK-MEL-5	GI₅₀	1.22 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human SK-MEL-5 cells by sulforhodamine B assay Growth inhibition of human SK-MEL-5 cells by sulforhodamine B assay	[PMID: 23644211]
SK-OV-3	GI₅₀	1.8 x 10^-5 M Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human SKOV3 cells by sulforhodamine B assay Growth inhibition of human SKOV3 cells by sulforhodamine B assay	[PMID: 23644211]
SN12C	GI₅₀	3.47 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human SN12C cells by sulforhodamine B assay Growth inhibition of human SN12C cells by sulforhodamine B assay	[PMID: 23644211]
SNB-19	GI₅₀	4.67 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human SNB19 cells by sulforhodamine B assay Growth inhibition of human SNB19 cells by sulforhodamine B assay	[PMID: 23644211]
SNB-75	GI₅₀	1.42 x 10^-5 M Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human SNB75 cells by sulforhodamine B assay Growth inhibition of human SNB75 cells by sulforhodamine B assay	[PMID: 23644211]
SR	GI₅₀	3 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human SR cells by sulforhodamine B assay Growth inhibition of human SR cells by sulforhodamine B assay	[PMID: 23644211]
SW-620	GI₅₀	4.48 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human SW620 cells by sulforhodamine B assay Growth inhibition of human SW620 cells by sulforhodamine B assay	[PMID: 23644211]
T47D	GI₅₀	6.15 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human T47D cells by sulforhodamine B assay Growth inhibition of human T47D cells by sulforhodamine B assay	[PMID: 23644211]
TK-10	GI₅₀	5.37 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human TK10 cells by sulforhodamine B assay Growth inhibition of human TK10 cells by sulforhodamine B assay	[PMID: 23644211]
U-251	GI₅₀	3.99 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human U251 cells by sulforhodamine B assay Growth inhibition of human U251 cells by sulforhodamine B assay	[PMID: 23644211]
UACC-257	GI₅₀	4.81 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human UACC257 cells by sulforhodamine B assay Growth inhibition of human UACC257 cells by sulforhodamine B assay	[PMID: 23644211]
UACC-62	GI₅₀	1.73 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human UACC62 cells by sulforhodamine B assay Growth inhibition of human UACC62 cells by sulforhodamine B assay	[PMID: 23644211]
UO-31	GI₅₀	3.44 μM Compound: 1, Lantadene A, NCS:D-764049/1,	Growth inhibition of human UO31 cells by sulforhodamine B assay Growth inhibition of human UO31 cells by sulforhodamine B assay	[PMID: 23644211]
Vero	IC₅₀	> 50 μM Compound: 1	Cytotoxicity against Chlorocebus aethiops (African green monkey) Vero cells assessed as growth inhibition after 48 hr by MTT assay Cytotoxicity against Chlorocebus aethiops (African green monkey) Vero cells assessed as growth inhibition after 48 hr by MTT assay	10.1007/s00044-012-0354-x

分子量

552.78

Formula

C₃₅H₅₂O₅

CAS 号

467-81-2

性状

固体

颜色

White to off-white

结构分类

初始来源

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: ≥96.0%

选择批次：

Data Sheet (526 KB) SDS (251 KB)

COA (267 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Barton, D. H. R., et al. Triterpenoids. Part XXIII. The nature of lantadene A.

[2]. Grace-Lynn C, et al. In vitro antioxidant activity potential of lantadene A, a pentacyclic triterpenoid of Lantana plants. Molecules. 2012;17(9):11185-11198.

Rehmannic acid 相关分类

Inflammation/Immunology

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rehmannic acid467-81-2Lantadene AOthersLantana camaraantioxidanthepatoprotective agentInhibitorinhibitorinhibit

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Rehmannic acid (Synonyms: Lantadene A)

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Rehmannic acid (Synonyms: Lantadene A)

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Rehmannic acid 相关分类

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The molarity calculator equation

The dilution calculator equation

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