2. Vitamin D Related/Nuclear Receptor Apoptosis Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Estrogen Receptor/ERR Apoptosis Reactive Oxygen Species
  4. rel-Levormeloxifene

rel-Levormeloxifene  (Synonyms: rel-L-Centchroman; Ormeloxifene)

目录号: HY-122359A
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摩尔计算器

rel-Levormeloxifene (rel-L-Centchroman) 是 Levormeloxifene (HY-122359) 的相对构型。rel-Levormeloxifene 是雌激素受体 (estrogen receptor) 的选择性调节剂 (SERM)。rel-Levormeloxifene 抑制白血病细胞的增殖，IC50 大约为 7 μM，在 G0/G1 期阻滞细胞周期，诱导细胞凋亡 (apoptosis)。rel-Levormeloxifene 髓系诱导白血病细胞的分化，在 K562 细胞中诱导 ROS 的产生。

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rel-Levormeloxifene Chemical Structure

rel-Levormeloxifene Chemical Structure

CAS No. : 31477-60-8

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Other Forms of rel-Levormeloxifene:

rel-Levormeloxifene 相关抗体

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

rel-Levormeloxifene (rel-L-Centchroman) is the relative configuration of Levormeloxifene (HY-122359). rel-Levormeloxifene is a selective estrogen receptor modulator (SERM). rel-Levormeloxifene inhibits proliferation of leukemia cells with IC50 about 7 μM, arrests cell cycle at G0/G1 phase, and induces apoptosis. rel-Levormeloxifene induces differentation of myelogenesis leukemia, and enhances ROS production in K562 cells[1].

分子量

457.60

Formula

C30H35NO3
CAS 号
中文名称

苯并吡喃
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

rel-Levormeloxifene 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

rel-Levormeloxifene31477-60-8rel-L-Centchroman Ormeloxifene苯并吡喃Estrogen Receptor/ERRApoptosisReactive Oxygen SpeciesK562U937HL60HEK293Tleukemiaanti-leukemiaSERMInhibitorinhibitorinhibit

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