2. Metabolic Enzyme/Protease
  3. Renin
  4. Remikiren

Remikiren  (Synonyms: Ro 42-5892; Ro 42-5892/001)

目录号: HY-A0184
产品使用指南 技术支持

Remikiren (Ro 42-5892) 是一种口服有效的、高特异性的肾素抑制剂。Remikiren 能特异性地抑制人肾素和人血浆肾素，其IC50 值分别为 0.7 和 0.8 nM。Remikiren 还能降低钠耗竭的狨猴和松鼠猴的平均动脉血压。Remikiren 可用于高血压的研究。

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Remikiren Chemical Structure

Remikiren Chemical Structure

CAS No. : 126222-34-2

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Remikiren 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Remikiren (Ro 42-5892) is an orally active and highly specific renin inhibitor. Remikiren specifically inhibits human reninand human plasma renin with IC50 values of 0.7 and 0.8 nM, respectively. Remikiren also reduces mean arterial blood pressure in sodium-depleted marmosets and squirrel monkeys. Remikiren can be used in study of hypertension[1].

IC50 & Target

IC50:0.7 nM (human pure renin), 0.8 nM (plasma renin of human)[1].
体外研究
(In Vitro)

Remikiren (0-10 nM; 1-3 h) displays a considerable specificity to inhibit renin[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Remikiren 相关抗体:

Cell Viability Assay[1]

Cell Line: Human pure renin, plasma renin of human, marmoset, squirrel monkey
Concentration: 0-10 nM
Incubation Time: 1-3 h
Result: Inhibited human pure renin and plasma renin of human, marmoset, squirrel monkey with IC50 values of 0.7, 0.8, 1.0 and 1.7 nM, respectively.
体内研究
(In Vivo)

Remikiren (0.1, 0.3, 1, 3, 10 mg/kg; p.o.; single) reduces mean arterial blood pressure in a dose-dependent manner in sodium-depleted marmosets and squirrel monkeys[1].
Remikiren (3 mg/kg; p.o.; single) shows the duration of blood pressure decrease more than 24 h in sodium-depleted marmosets[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Marmosets and squirrel monkeys (sodium-depleted)[1].
Dosage: 0.1, 0.3, 1, 3, 10 mg/kg
Administration: Oral administration; single.
Result: Decreased mean arterial pressure (MAP) by 20-25 mm Hg when at 0.1 mg/kg.
Reached the maximal decrease (30 mm Hg) of MAP with 1 mg/kg in marmosets.
Decreasesd 35 mm Hg blood pressure with 3-10 mg/kg in squirrel monkeys.
Animal Model: Marmosets (sodium-depleted)[1].
Dosage: 3 mg/kg
Administration: Oral administration; single.
Result: Showed MAP fell by 30 mm Hg, which lasting more than 24 h.
分子量

630.84

Formula

C33H50N4O6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Remikiren 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Remikiren126222-34-2Ro 42-5892 Ro 42-5892/001Reninhypertensionblood pressureInhibitorinhibitorinhibit

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