2. Anti-infection Apoptosis
  3. Antibiotic Apoptosis Bacterial
  4. Resistomycin

Resistomycin 是一种五环聚酮抗生素，具有抗癌活性并诱导癌细胞凋亡。

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Resistomycin Chemical Structure

Resistomycin Chemical Structure

CAS No. : 20004-62-0

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规格 价格 是否有货 数量
1 mg ￥3870
3 - 4 周
5 mg   询价  
10 mg   询价  

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Resistomycin 相关抗体

Top Publications Citing Use of Products

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

生物活性

Resistomycin, a pentacyclic polyketide antibiotic, possesses anticancer activity and induces apoptosis[1][2][3][4].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CCRF-CEM IC50
0.5 μM
Compound: 5
Antiproliferative activity against human CEM cells assessed as growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human CEM cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 33974416]
CCRF-CEM IC50
0.5 μM
Compound: 1
Antiproliferative activity against human CEM cells after 72 hrs by MTT assay
Antiproliferative activity against human CEM cells after 72 hrs by MTT assay
[PMID: 29137865]
HCT-116 IC50
0.1 μM
Compound: 1
Antiproliferative activity against p53 deficient human HCT116 cells after 72 hrs by MTT assay
Antiproliferative activity against p53 deficient human HCT116 cells after 72 hrs by MTT assay
[PMID: 29137865]
HCT-116 IC50
0.3 μM
Compound: 1
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
[PMID: 29137865]
HeLa IC50
0.1 μM
Compound: 5
Antiproliferative activity against human HeLa cells assessed as growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 33974416]
HeLa IC50
0.1 μM
Compound: 1
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
[PMID: 29137865]
HMEC-1 IC50
0.5 μM
Compound: 5
Cytotoxicity against human HMEC-1 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HMEC-1 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 33974416]
HMEC-1 IC50
0.5 μM
Compound: 1
Antiproliferative activity against HMEC1 cells after 72 hrs by MTT assay
Antiproliferative activity against HMEC1 cells after 72 hrs by MTT assay
[PMID: 29137865]
K562 IC50
0.3 μM
Compound: 1
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
[PMID: 29137865]
L1210 IC50
0.7 μM
Compound: 5
Antiproliferative activity against mouse L1210 cells assessed as growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against mouse L1210 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 33974416]
L1210 IC50
0.7 μM
Compound: 1
Antiproliferative activity against mouse L1210 cells after 72 hrs by MTT assay
Antiproliferative activity against mouse L1210 cells after 72 hrs by MTT assay
[PMID: 29137865]
T-24 IC50
26 μM
Compound: 1
Growth inhibition of human T24 cells after 72 hrs by cell impedance method
Growth inhibition of human T24 cells after 72 hrs by cell impedance method
[PMID: 29137865]
体外研究
(In Vitro)

Resistomycin attenuates triple-negative breast cancer progression by inhibiting E3 ligase Pellino-1 and inducing SNAIL/SLUG degradation[1].
Resistomycin displays a high affinity for GST-Pellino-1 (KD = 2.58 μM) as indicated by surface plasmon resonance[1].
Resistomycin treatment reduced the expression of SNAIL and SLUG in TNBC cells[1].
Resistomycin induced apoptosis and cycle arrest in human hepatocellular carcinoma cells by activating p38 MAPK pathway in vitro and in vivo[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Resistomycin 相关抗体:
分子量

376.36

Formula

C22H16O6
CAS 号
结构分类
初始来源

Streptomyces sulphureus
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Resistomycin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Resistomycin20004-62-0AntibioticApoptosisBacterialapoptosiscell cycle arrestTNBCSNAILSLUGInhibitorinhibitorinhibit

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