Resolvin D1  (Synonyms: RvD1)

Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages^[1][2].

Resolvin D1 (RvD1) (1-100 nM；15 分钟) 在原代人巨噬细胞中诱导剂量依赖性短期功能变化。RvD1 触发细胞内 Ca²⁺ 释放，阻断趋化性迁移，并刺激微生物颗粒的吞噬作用，在 10 nM时效率最高^[1]。
Resolvin D1 (0-500 nM；72 小时) 在 RAW264.7 巨噬细胞中显示出不同浓度的 RvD1 对 LPS 诱导的 TRAP 和组织蛋白酶 K 表达的强烈抑制作用^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Resolvin D1 (RvD1) (100-1000 ng；腹腔注射；第 10 天每天) 改善关节炎小鼠的 RA (类风湿性关节炎) 临床终点^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

376.49

C₂₂H₃₂O₅

872993-05-0

液体

Colorless to light yellow

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

• [1]. Schmid M, et al. Resolvin D1 Polarizes Primary Human Macrophages toward a Proresolution Phenotype through GPR32. J Immunol. 2016 Apr 15;196(8):3429-37.  [Content Brief]

  [2]. Gao Y, et al. Resolvin D1 Improves the Resolution of Inflammation via Activating NF-κB p50/p50-Mediated Cyclooxygenase-2 Expression in Acute Respiratory Distress Syndrome. J Immunol. 2017 Aug 9. pii: ji1700315.  [Content Brief]

  [3]. Benabdoun HA, et al. In vitro and in vivo assessment of the proresolutive and antiresorptive actions of resolvin D1: relevance to arthritis. Arthritis Res Ther. 2019 Mar 12;21(1):72.  [Content Brief]