2. Anti-infection
  3. Bacterial
  4. Resolvin D4

Resolvin D4 (RvD4) 是一种特异性的促解素介质，可以在金黄色葡萄球菌感染期间产生生物活性水平。

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Resolvin D4 Chemical Structure

Resolvin D4 Chemical Structure

CAS No. : 1025684-60-9

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Resolvin D4 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Resolvin D4 (RvD4), a specialized proresolving mediator, can be produced in bioactive levels during S. aureus infection[1].
体外研究
(In Vitro)

Resolvin D4 (RvD4) 在无菌腹膜炎和金黄色葡萄球菌皮肤感染中阻止中性粒细胞浸润[1].
Resolvin D4 (RvD4, 0-10 nM) 增强人类巨噬细胞和皮肤成纤维细胞吞噬和吞噬作用[1].
Resolvin D4 (RvD4, 0-10 nM) 显著增加了巨噬细胞对凋亡中性粒细胞的吞噬作用，增加了40-50%[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Resolvin D4 相关抗体:
体内研究
(In Vivo)

Resolvin D4 (RvD4, 3 µg/mouse) 调节体内血栓炎症性疾病的严重程度，并改善血栓溶解[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8-week-old male FVB mice (a self-limited bacterial inoculation (105 c.f.u) into the dorsal pouch)[1].
Dosage: 200 ng/mouse (saline containing 0.01% EtOH).
Administration: I.P..
Result: Gave lower PMN levels in the cavity in mice treated with RvD4.
Significantly lowered bacterial counts when compared to vehicle control.
Stopped leukocyte influx to the site of infection in the dorsal pouch cavity as well as the inflammation-initiating eicosanoids by reducing levels of PGD2 and LTB4.
Animal Model: Thrombus-bearing mice[2].
Dosage: 3 µg.
Administration: IV via tail vein injection on day 1 and day 4 after IVC stenosis.
Result: Accelerated venous thrombus resolution in mice.
分子量

376.49

Formula

C22H32O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Resolvin D4 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Resolvin D41025684-60-9RvD4Resolvin D 4Resolvin D-4RvD 4RvD-4Bacterialproresolving mediatorneutrophil infiltrationphagocytosisefferocytosisthrombus resolutionInhibitorinhibitorinhibit

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