2. Protein Tyrosine Kinase/RTK
  3. RET
  4. RET-IN-13

RET-IN-13 (compound 1) 是一种喹啉化合物，一种有效的 RET 抑制剂，对 RET (WT) 和 RET (V804M) 的 IC50 分别为 0.5 nM 和 0.9 nM。RET-IN-13 具有用于与 RET 异常激活相关的肿瘤或肠道疾病研究的潜力。

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RET-IN-13 Chemical Structure

RET-IN-13 Chemical Structure

CAS No. : 2684258-54-4

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RET-IN-13 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RET-IN-13 (compound 1), a quinoline compound, is a potent RET inhibitor with IC50s of 0.5 nM, 0.9 nM for RET (WT) and RET (V804M), respectively. RET-IN-13 has the potential for tumors or intestinal diseases related to abnormal activation of RET research[1].

体外研究
(In Vitro)

RET-IN-13 has low inhibition on CYP1A2 (IC50>50 μM), CYP2C9 (IC50=12.5 μM), CYP2C19 (IC50=16.9 μM), CYP2D6 (IC50=18.8 μM) and CYP3A4 (IC50>50 μM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RET-IN-13 相关抗体:
体内研究
(In Vivo)

RET-IN-13 (compound 1; 0.5 mpk; iv) has a T1/2 of 6.93 hours, a CL of 2.68 mL/min·kg, and a Vdss of 1.52 L/kg for male mice[1].
RET-IN-13 (2.5 mpk; po) has a T1/2 of 5.16 hours, Cmax of 0.958 μM and an AUC of 12477 μM·hr for male mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

611.63

Formula

C32H33F4N5O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RET-IN-13 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RET-IN-132684258-54-4RETQuinolineV804Mtumorsintestinal diseasesInhibitorinhibitorinhibit

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