1. Anti-infection
  2. Bacterial
  3. Reveromycin B

Reveromycin B 是一种螺旋缩酮细菌代谢物,最初从链霉菌中分离出来。它可抑制 Balb/MK 细胞中 EGF 诱导的有丝分裂活性(IC50=6 μg/mL),并表现出针对白色念珠菌的 pH 依赖性抗真菌活性(在 pH 3.0 和 7.4 时,MIC 分别为 15.6 和 >500 μg/mL)。与瑞维霉素 A 和瑞维霉素 C 不同,Reveromycin B 不会抑制 KB 和 K562 细胞的增殖。

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Reveromycin B Chemical Structure

Reveromycin B Chemical Structure

CAS No. : 144860-68-4

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Reveromycin B is a spiroketal bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells (IC50=6 μg/mL) and exhibits pH-dependent antifungal activity against C. albicans (MICs=15.6 and >500 μg/mL at pH 3.0 and 7.4, respectively). Unlike reveromycin A and reveromycin C, reveromycin B does not inhibit proliferation of KB and K562 cells.

分子量

660.79

Formula

C36H52O11

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Reveromycin B 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Reveromycin B
目录号:
HY-125066
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