2. Anti-infection
  3. HIV
  4. Reverse transcriptase-IN-3

Reverse transcriptase-IN-3 是一种嘧啶-5-羧酰胺衍生物，是 HIV-1 的抑制剂。Reverse transcriptase-IN-3 对 HIV-1 野生型和突变型病毒株显示出有效的抑制活性。

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Reverse transcriptase-IN-3 Chemical Structure

Reverse transcriptase-IN-3 Chemical Structure

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Reverse transcriptase-IN-3 相关抗体

Top Publications Citing Use of Products

查看 HIV 亚型特异性产品:

查看所有亚型
HIV HIV-1 HIV-2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Reverse transcriptase-IN-3 is a pyrimidine-5-carboxamide derivative, acts as an inhibitor of HIV-1. Reverse transcriptase-IN-3 shows potent activity against the HIV-1 wild-type and mutant strains[1].

IC50 & Target[1]

HIV (IIIB)

8 nM (EC50)

HIV-1 (L100I)

65 nM (EC50)

HIV-1 (K103N)

9 nM (EC50)

HIV-1 (Y181C)

45 nM (EC50)

HIV-1 (Y188L)

35 nM (EC50)

HIV-1 (E138K)

0.734 μM (EC50)

HIV-1 (F227L+V106A)

34 nM (EC50)

HIV-1 (RES056)

42 nM (EC50)

体外研究
(In Vitro)

Reverse transcriptase-IN-3 (化合物21c) (EC50=0.009-0.065 μM) 对 HIV-1 IIIB (8 nM)、L100I (65 nM)、K103N (9 nM)、Y181C (45 nM)、Y188L (35 nM) 和 RES056 (42 nM) 的抑制活性最强，与 Etravirine (HY-90005) 相当[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Reverse transcriptase-IN-3 相关抗体:
分子量

561.66

Formula

C28H31N7O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Reverse transcriptase-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Reverse transcriptase-IN-3HIVHuman immunodeficiency virusInhibitorinhibitorinhibit

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产品名称：
Reverse transcriptase-IN-3
目录号：
HY-151938
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