2. Immunology/Inflammation
  3. Interleukin Related
  4. Risankizumab

Risankizumab  (Synonyms: 瑞莎珠单抗; Risankizumab rzaa; BI 655066)

目录号: HY-P99248 纯度: 99.37%
COA

摩尔计算器

Risankizumab (BI 655066) 是一种人源化 IgG 单克隆抗体，靶向 IL-23 p19 亚基(Kd <10 pM)，并能抑制人 IL-23 在小鼠脾细胞中诱导的 IL-17 产生(IC50 = 2 pM)。Risankizumab 可用于研究免疫性和炎症性疾病，如寻常型银屑病、银屑病关节炎、广泛性脓疱型银屑病和红皮病型银屑病。

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CAS No. : 1612838-76-2

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1 mg ￥5800
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Risankizumab 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Risankizumab (BI 655066) is a humanised IgG monoclonal antibody, targeting IL-23 p19 subunit (Kd <10 pM) and inhibiting IL-17 production induced by human IL-23 in mouse splenocytes (IC50 = 2 pM). Risankizumab can be used to research immunological and inflammatory disorders such as psoriasis vulgaris, psoriatic arthritis, generalized pustular psoriasis and erythrodermic psoriasis[1][2][3].

同型

Human IgG1 kappa
推荐同型对照抗体
种属

Humanized
IC50 & Target[3]

IL-23

<10 pM (Kd)

体外研究
(In Vitro)

Risankizumab (BI 655066) has a high affinity for human and cynomolgus IL23 with Kds <10 pM[3].
Risankizumab (BI 655066) inhibits endogenous (THP-1 cell generated) human IL23-induced and recombinant cynomolgus IL23-induced IL17 production with IC50s of 2 pM and 17 pM, respectively[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Risankizumab 相关抗体:
体内研究
(In Vivo)

Risankizumab (BI 655066) (1 mg/kg; i.p.; single dosage) inhibits IL23-induced mice ear swelling and cytokine production[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice (injected with BI 655066, 1 h later injected recombinant human IL23 into the skin of the mouse ear for 4 days)[3]
Dosage: 1 mg/kg
Administration: i.p.; single dosage
Result: Significantly inhibited IL23-induced ear swelling and cytokine production.
Animal Model: Cynomolgus monkeys[3]
Dosage: 1.0 mg/kg
Administration: i.v. or s.c.
Result: Pharmacokinetic Parameters of Risankizumab (BI 655066) in cynomolgus monkeys[1].
IV (1 mg/kg) SC (1 mg/kg)
AUCinf (μg·day/mL) 202 ± 33.5 142 ± 33.3
CL (mL/day/kg) 5.18 ± 0.8 /
Vd, ss (mL/kg) 88.3 ± 3.12 /
t1/2 (h) 12.2 ± 2.28/ 9.15 ± 1.87
Cmax (μg/mL) / 10.1 ± 3.14
Tmax (day) / 2.11 ± 1.84
F (%) / 70.4 ± 16.5
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

瑞莎珠单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
纯度 & 产品资料

纯度: 99.37%

COA (172 KB) SDS-PAGE (79 KB) SEC-HPLC (88 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Risankizumab 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Risankizumab1612838-76-2Risankizumab rzaa BI 655066瑞莎珠单抗BI655066BI 655066BI-655066Interleukin RelatedILIL-23psoriasisswellingcytokineCynomolgus monkeysInhibitorinhibitorinhibit

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