2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. RN-9893 hydrochloride

RN-9893 Hydrochloride 是一种具有口服活性的 TRPV4 拮抗剂，在人和大鼠体内的 IC50 值分别为 0.42 μM 和 0.66 μM。

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RN-9893 hydrochloride Chemical Structure

RN-9893 hydrochloride Chemical Structure

CAS No. : 2109450-40-8

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RN-9893 hydrochloride 的其他形式现货产品:

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RN-9893 hydrochloride 相关抗体

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TRPC TRPM TRPV TRPA TRPML

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RN-9893 Hydrochloride is an orally active antagonist of transient receptor potential vanilloid 4 (TRPV4), with IC50 values of 0.42 and 0.66 μM, for humans and rats, respectively[1].

体外研究
(In Vitro)

RN-9893 Hydrochloride 具有选择性，对TRPV1，TRPV3 和 TRPM8 的 IC50 值分别是 10 μM，>30 μM 和 30 μM[1]。
RN-9893 Hydrochloride 可以使用 4α-PDD 和 20% hypotonicity 作为激动剂抑制 rTRPV4，IC50 分别是 0.57 μM 和 2.1 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RN-9893 hydrochloride 相关抗体:
分子量

536.95

Formula

C21H24ClF3N4O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RN-9893 hydrochloride 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RN-98932109450-40-8RN9893RN 9893TRP ChannelTransient receptor potential channelsTRPVTRPV44α-PDD20% hypotonicityInhibitorinhibitorinhibit

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目录号：
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