2. Membrane Transporter/Ion Channel
  3. P2X Receptor
  4. Ro-51

Ro-51 是一种高效、选择性的 P2X3/P2X2/3 双重拮抗剂，对 P2X3 和 P2X2/3 作用的IC50 值分别为 2 nM 和 5 nM。Ro-51 可以用于痛觉研究。

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Ro-51 Chemical Structure

Ro-51 Chemical Structure

CAS No. : 1050670-85-3

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规格 价格 是否有货 数量
5 mg ￥3832
3 - 4 周
10 mg 现货 3 - 4 周
50 mg   询价  
100 mg   询价  

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Ro-51 相关抗体

Top Publications Citing Use of Products

查看 P2X Receptor 亚型特异性产品:

查看所有亚型
P2X1 Receptor P2X2 Receptor P2X3 Receptor P2X4 Receptor P2X7 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ro-51 is a potent and selective dual P2X3/P2X2/3 antagonist, with IC50 of 2 nM and 5 nM for P2X3 and P2X2/3, respectively. Ro-51 can be used for the research for pain[1][2].

IC50 & Target

IC50: 2 nM (P2X3), 5 nM (P2X2/3)[1]
体外研究
(In Vitro)

Ro-51 has highly selective for P2X 3 and P2X 2/3 exhibiting no antagonistic activity at other P2X receptor family members tested (P2X 1 , P2X 2 , P2X 4 , P2X 5 , and P2X 7 ) at concentrations up to 10 μM[1].
RO51 also shows a significant drop in potency on human P2X3 receptors (IC50 = 110.5 and 0.04 nM, respectively for human and rat P2X3)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ro-51 相关抗体:
体内研究
(In Vivo)

Ro-51 suffers rapid clearance, short half-lives, and high protein binding in rat[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat[1]
Dosage: 2 mg/kg (Pharmacokinetic Analysis)
Administration: Oral administration
Result: AUC= 237 ng/h/mL, T 1/2 =1.52 h
分子量

474.29

Formula

C17H23IN4O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ro-51 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ro-511050670-85-3Ro51Ro 51P2X ReceptorP2XRsP2X(3)P2X(2/3)painhyperalgesiamechanicalallodyniainflammatoryneuropathicmodelsInhibitorinhibitorinhibit

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产品名称：
Ro-51
目录号：
HY-14485
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