2. Apoptosis
  3. Apoptosis
  4. Ropeginterferon alfa-2b

Ropeginterferon alfa-2b  (Synonyms: Ropeginterferon alfa-2b-njft; PEG-proline-interferon alpha-2b)

目录号: HY-P99348
COA

摩尔计算器

Ropeginterferon alfa-2b (Ropeginterferon alfa-2b-njft) 是一种单聚乙二醇化的 IFN-α，可用于骨髓增性肿瘤的研究。

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CAS No. : 1335098-50-4

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规格 价格 是否有货
250 μg ￥65000
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Ropeginterferon alfa-2b 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ropeginterferon alfa-2b (Ropeginterferon alfa-2b-njft) is a monopegylated IFN-α that can be used for the research of myeloproliferative neoplasms[1].

种属

Human
体外研究
(In Vitro)

Ropeginterferon alfa-2b (5 μg/mL; 72 h) 抑制 BA-1 细胞生长，诱导细胞凋亡，使细胞周期阻滞于 G1 期[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ropeginterferon alfa-2b 相关抗体:

Cell Proliferation Assay[1]

Cell Line: BA-1 cells
Concentration: 5 μg/mL
Incubation Time: 72 h
Result: Suppressed BA-1 growth.

Apoptosis Analysis[1]

Cell Line: BA-1 cells
Concentration: 5 μg/mL
Incubation Time: 24, 48 and 72 h
Result: Showed an increase in early- and late-apoptotic cells in a time-dependent manner. Promoted a time-dependent increase in caspase-3 expression.

Cell Cycle Analysis[1]

Cell Line: BA-1 cells
Concentration: 5 μg/mL
Incubation Time: 24, 48 and 72 h
Result: Induced an increase in G1 phase.
体内研究
(In Vivo)

Ropeginterferon alfa-2b (5 μg/mouse; s.c.; single dose) 降低白血病负担，延长白血病小鼠存活时间[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice (8-12 weeks) with BA-1 cells[1]
Dosage: 5 μg/mouse
Administration: Subcutaneous injection, on day 5 after tumor inoculation
Result: Led to long-term remission in four of eight (50%) mice.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • IFNA2 (interferon alpha 2)*b (R46,H57)24-188 R46
纯度 & 产品资料
参考文献

Ropeginterferon alfa-2b 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ropeginterferon alfa-2b1335098-50-4Ropeginterferon alfa-2b-njft PEG-proline-interferon alpha-2bApoptosismyeloproliferative neoplasmsIFN-αBA-1Inhibitorinhibitorinhibit

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