2. GPCR/G Protein Neuronal Signaling Others
  3. Dopamine Receptor Isotope-Labeled Compounds
  4. Ropinirole-d14 hydrochloride

Ropinirole-d14 hydrochloride  (Synonyms: 盐酸罗匹尼罗-d14; SKF 101468-d14 hydrochloride)

目录号: HY-B0623AS3
产品使用指南

摩尔计算器

Ropinirole-d14 hydrochloride 是氘代标记的 Ropinirole hydrochloride (HY-B0623A)。Ropinirole (SKF 101468) hydrochloride 是一种口服有效的 D3/D2 受体激动剂，对 D2 受体的 Ki 为 29 nM。Ropinirole hydrochloride 对 hD2，hD3 和 hD4 受体的 pEC50 分别为 7.4、8.4 和 6.8。Ropinirole hydrochloride 对 D1 受体没有亲和力。Ropinirole hydrochloride 具有用于帕金森氏病潜力。

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Ropinirole-d<sub>14</sub> hydrochloride Chemical Structure

Ropinirole-d14 hydrochloride Chemical Structure

CAS No. : 1276197-10-4

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Other Forms of Ropinirole-d14 hydrochloride:

Ropinirole-d14 hydrochloride 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Ropinirole-d14 hydrochloride is deuterated labeled Ropinirole hydrochloride (HY-B0623A). Ropinirole (SKF 101468) hydrochloride is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor. Ropinirole hydrochloride has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole hydrochloride has no affinity for the D1 receptors. Ropinirole hydrochloride has the potential for Parkinson's disease[1][2].

体外研究
(In Vitro)

氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ropinirole-d14 hydrochloride 相关抗体:
体内研究
(In Vivo)

Ropinirole (0.1-10 mg/kg; i.p.) decreases intracranial self-stimulation (ICSS) thresholds and induces anxiolytic- and antidepressive-like effects without affecting motor activity or spatial memory[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

310.92

Formula

C16H11D14ClN2O
CAS 号
非标记 CAS

91374-20-8
中文名称

盐酸罗匹尼罗-d14
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ropinirole-d14 hydrochloride 相关分类

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Keywords:

Ropinirole-d141276197-10-4SKF 101468-d14盐酸罗匹尼罗-d14Dopamine ReceptorIsotope-Labeled CompoundsD3D2D1D4Parkinson'sdiseaseInhibitorinhibitorinhibit

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