2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis
  3. Reactive Oxygen Species Mitochondrial Metabolism Apoptosis
  4. ROS inducer 4

ROS inducer 4 (compound TE3) 是一种线粒体抑制剂。ROS inducer 4 可导致肿瘤发生一系列与线粒体相关的生理变化，如线粒体碎裂、ROS 的爆发性产生和积累、线粒体膜电位降低、ATP 含量降低以及线粒体中 ROS 介导的凋亡信号的激活。

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ROS inducer 4 Chemical Structure

ROS inducer 4 Chemical Structure

CAS No. : 2959444-40-5

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ROS inducer 4 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ROS inducer 4 (compound TE3) is a mitochondrial inhibitor. ROS inducer 4 causes a series of mitochondria-related physiological changes in tumors, such as mitochondrial fragmentation, explosive generation and accumulation of ROS, decreased mitochondrial membrane potential, decreased ATP content, and activation of ROS-mediated apoptotic signaling in mitochondria[1].

体外研究
(In Vitro)

ROS inducer 4 (compound TE3) 对 HeLa、A549 和 HCT-15 细胞表现出抗癌活性，IC50 值分别为 4.83、3.49 和 8.74 μM[1]。
ROS inducer 4 (8 µM) 通过诱导 ROS 破坏 HeLa 细胞中的线粒体功能[1]。
ROS inducer 4 (1-8 µM) 以剂量依赖性方式诱导 HeLa 细胞中的细胞凋亡[1]。
与母体分子Ergosterol peroxide (HY-N3845)相比，ROS inducer 4 表现出大大增强的抗癌活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ROS inducer 4 相关抗体:
体内研究
(In Vivo)

ROS inducer 4 (compound TE3) 在C57BL/6雌性小鼠中的LD50为70mg/kg，95%置信区间为59.29-97.9mg/kg[1]。
ROS inducer 4 (1-2mg/kg) 比 Cisplatin (HY-17394) 具有更好的抗宫颈癌活性和安全性，并能激活小鼠的免疫反应[1]。
ROS inducer 4 具有中等毒性，ROS inducer 4 在有效剂量 (1 mg/kg) 下无明显毒性作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

825.89

Formula

C49H62BrO4P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ROS inducer 4 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ROS inducer 42959444-40-5ROS inducer4ROS inducer-4Reactive Oxygen SpeciesMitochondrial MetabolismApoptosiscervical cancermitochondrialROSHeLaA549HCT-15Inhibitorinhibitorinhibit

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