2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. RS-25344

RS-25344 是一种第四型磷酸二酯酶 (PDE4) 选择性抑制剂。RS-25344 通过抑制 PDE4 的活性，来增加细胞内 cAMP (环磷酸腺苷) 的浓度。RS-25344 可用于炎症、免疫性疾病、神经退行性疾病和心血管疾病的研究。

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RS-25344 Chemical Structure

RS-25344 Chemical Structure

CAS No. : 152814-89-6

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RS-25344 的其他形式现货产品:

Other Forms of RS-25344:

RS-25344 相关抗体

Top Publications Citing Use of Products

查看 Phosphodiesterase (PDE) 亚型特异性产品:

查看所有亚型
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RS-25344 is a selective inhibitor of phosphodiesterase type IV (PDE4). RS-25344 increases intracellular cAMP (cyclic adenosine phosphate) concentration by inhibiting PDE4 activity. RS-25344 can be used in the study of inflammation, immune diseases, neurodegenerative diseases and cardiovascular diseases[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Sf9 IC50
19 nM
Compound: 27; CHEMBL1232082
Inhibition of recombinant human PDE4D7 catalytic domain expressed in baculovirus infected sf9 cells using cAMP as substrate
Inhibition of recombinant human PDE4D7 catalytic domain expressed in baculovirus infected sf9 cells using cAMP as substrate
[PMID: 26908025]
分子量

375.34

Formula

C19H13N5O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RS-25344 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RS-25344152814-89-6RS25344RS 25344Phosphodiesterase (PDE)Selective inhibitorcAMPinfertilityinflammationneurodegenerative diseasesPDE4Inhibitorinhibitorinhibit

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产品名称：
RS-25344
目录号：
HY-69172
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