2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. RS-64459-193

RS-64459-193 是一种 5-HT1A 受体部分激动剂，Ki 为 24.9 nM。RS-64459-193 还对 5-HT2C、5-HT2A 和 5-HT7 表现出高亲和力，pKi 值分别为 6.87、7.02 和 7.18。RS-64459-193 对 m 5-HT3 受体几乎没有活性。

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RS-64459-193 Chemical Structure

RS-64459-193 Chemical Structure

CAS No. : 123882-89-3

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RS-64459-193 相关抗体

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查看 5-HT Receptor 亚型特异性产品:

查看所有亚型
5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RS-64459-193 is a 5-HT1A receptor partial agonist with a Ki of 24.9 nM. RS-64459-193 also shows high affinity for 5-HT2C, 5-HT2A and 5-HT7 with pKi values of 6.87, 7.02, and 7.18, respectively. RS-64459-193 is almost devoid of activity at the m 5-HT3 receptor[1].

IC50 & Target[1]

5-HT1A Receptor

24.9 nM (Ki, CHO cells)

human 5-HT1A Receptor

7.6 (pKi, Sf9)

human 5-HT1A Receptor

7.04 (pKi)

5-HT2C Receptor

6.87 (pKi)

Rat 5-HT2A

7.02 (pKi)

Human 5-HT7 Receptor

7.18 (pKi)

5-HT3 Receptor

<4 (pKi)

分子量

479.48

Formula

C26H36Cl2N2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RS-64459-193 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RS-64459-193123882-89-35-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT1A AgonistInhibitorinhibitorinhibit

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产品名称：
RS-64459-193
目录号：
HY-120498
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