2. Membrane Transporter/Ion Channel
  3. Na+/H+ Exchanger (NHE)
  4. RS5517

RS5517 是 NHERF1 的特异性 PDZ1 结构域拮抗剂，可阻止其异位核进入。RS5517 可用于大肠癌的研究。

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RS5517 Chemical Structure

RS5517 Chemical Structure

CAS No. : 2227017-46-9

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RS5517 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RS5517 is a specific PDZ1-domain antagonist of NHERF1 that prevented its ectopic nuclear entry. RS5517 can be used for the research of colorectal cancer[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
DLD-1 IC50
0.1 μM
Compound: 15
Growth inhibition of human DLD1 cells without NHERF1 expression incubated for 72 hrs in presence of Ethyl 4-((4-bromophenyl)sulfonamido)benzoate by MTT assay
Growth inhibition of human DLD1 cells without NHERF1 expression incubated for 72 hrs in presence of Ethyl 4-((4-bromophenyl)sulfonamido)benzoate by MTT assay
[PMID: 30996786]
DLD-1 IC50
0.5 μM
Compound: 15
Growth inhibition of human DLD1 cells without NHERF1 expression incubated for 72 hrs in presence of FH535 by MTT assay
Growth inhibition of human DLD1 cells without NHERF1 expression incubated for 72 hrs in presence of FH535 by MTT assay
[PMID: 30996786]
DLD-1 IC50
65 μM
Compound: 15
Growth inhibition of human DLD1 cells without NHERF1 expression incubated for 72 hrs by MTT assay
Growth inhibition of human DLD1 cells without NHERF1 expression incubated for 72 hrs by MTT assay
[PMID: 30996786]
LS174T IC50
52 μM
Compound: 15
Inhibition of NHERF1 in human Ls174T cells stably transfected with Dox-inducible shRNA for beta-catenin (Ls174Tsh-beta-Cat) assessed as inhibition of cell growth incubated for 72 hrs by absence of doxycycline by MTT assay
Inhibition of NHERF1 in human Ls174T cells stably transfected with Dox-inducible shRNA for beta-catenin (Ls174Tsh-beta-Cat) assessed as inhibition of cell growth incubated for 72 hrs by absence of doxycycline by MTT assay
[PMID: 30996786]
LS174T IC50
8 μM
Compound: 15
Inhibition of NHERF1 in human Ls174T cells stably transfected with Dox-inducible shRNA for beta-catenin (Ls174Tsh-beta-Cat) assessed as inhibition of cell growth incubated for 72 hrs by presence of doxycycline by MTT assay
Inhibition of NHERF1 in human Ls174T cells stably transfected with Dox-inducible shRNA for beta-catenin (Ls174Tsh-beta-Cat) assessed as inhibition of cell growth incubated for 72 hrs by presence of doxycycline by MTT assay
[PMID: 30996786]
SW480 IC50
0.1 μM
Compound: 15
Growth inhibition of human SW480 cells expressing NHERF1 incubated for 72 hrs in presence of Ethyl 4-((4-bromophenyl)sulfonamido)benzoate by MTT assay
Growth inhibition of human SW480 cells expressing NHERF1 incubated for 72 hrs in presence of Ethyl 4-((4-bromophenyl)sulfonamido)benzoate by MTT assay
[PMID: 30996786]
SW480 IC50
0.9 μM
Compound: 15
Growth inhibition of human SW480 cells expressing NHERF1 incubated for 72 hrs in presence of FH53 by MTT assay
Growth inhibition of human SW480 cells expressing NHERF1 incubated for 72 hrs in presence of FH53 by MTT assay
[PMID: 30996786]
SW480 IC50
8 μM
Compound: 15
Growth inhibition of human SW480 cells expressing NHERF1 incubated for 72 hrs by MTT assay
Growth inhibition of human SW480 cells expressing NHERF1 incubated for 72 hrs by MTT assay
[PMID: 30996786]
SW-620 IC50
0.5 μM
Compound: 15
Growth inhibition of human SW620 cells expressing NHERF1 incubated for 72 hrs in presence of Ethyl 4-((4-bromophenyl)sulfonamido)benzoate by MTT assay
Growth inhibition of human SW620 cells expressing NHERF1 incubated for 72 hrs in presence of Ethyl 4-((4-bromophenyl)sulfonamido)benzoate by MTT assay
[PMID: 30996786]
SW-620 IC50
18 μM
Compound: 15
Growth inhibition of human SW620 cells expressing NHERF1 incubated for 72 hrs in presence of FH53 by MTT assay
Growth inhibition of human SW620 cells expressing NHERF1 incubated for 72 hrs in presence of FH53 by MTT assay
[PMID: 30996786]
分子量

390.86

Formula

C23H19ClN2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RS5517 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RS55172227017-46-9RS 5517RS-5517Na+/H+ Exchanger (NHE)Sodium/hydrogen ExchangerSodium-hydrogen Exchangercolorectal cancersEBP50NEM157-iInhibitorinhibitorinhibit

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RS5517
目录号：
HY-150269
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