2. Metabolic Enzyme/Protease
  3. E1/E2/E3 Enzyme
  4. Rugonersen sodium

Rugonersen sodium  (Synonyms: RG6091 sodium; RO7248824 sodium)

目录号: HY-148130A 纯度: 91.12%
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摩尔计算器

Rugonersen sodium 是一种锁定核酸 (LNA) 修饰的反义寡核苷酸 (ASOs)，可减少泛素蛋白连接酶 E3A (UBE3A) 沉默。Angelman 综合征 (AS) sodium 是一种由神经元 E3连接酶 UBE3A 缺失引起的严重神经发育障碍，Rugonersen 已用于 AS 的研究。

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DNA, d(P-thio)((2′-O,4′-C-methylene)m5rU-(2′-O,4′-C-methylene)m5rU-(2′-O,4′-C-methylene)rA-C-(2′-O,4′-C-methylene)rA-C-T-T-A-A-T-T-A-T-A-C-T-(2′-O,4′-C-methylene)m5rU-(2′-O,4′-C-methylene)m5rC-(2′-O,4′-C-methylene)m5rC), sodium salt

Rugonersen sodium Chemical Structure

CAS No. : 2591588-58-6

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规格 价格 是否有货 数量
1 mg ￥1140
In-stock
5 mg ￥3170
In-stock
10 mg ￥5080
In-stock
50 mg   询价  
100 mg   询价  

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Other Forms of Rugonersen sodium:

Rugonersen sodium 相关抗体

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  • 生物活性

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生物活性

Rugonersen sodium is a locked-nucleic acid (LNA)- modified antisense oligonucleotides (ASOs), and results in reduction of ubiquitin-protein ligase E3A (UBE3A) silencing. Angelman syndrome (AS) sodium is a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A, Rugonersen has been used for AS reasearch[1][2].

分子量

6948.00

Formula

C204H235N63Na19O109P19S19
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献

Rugonersen sodium 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rugonersen2591588-58-6RG6091RO7248824RG 6091RG-6091RO 7248824RO-7248824E1/E2/E3 EnzymeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseAngelman syndromeUBE3A-ATSlong lasting effectcynomolgus monkey AS human pluripotent stem cell neuronsInhibitorinhibitorinhibit

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Rugonersen sodium
目录号：
HY-148130A
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