2. Metabolic Enzyme/Protease Apoptosis
  3. Endogenous Metabolite Apoptosis
  4. S-Adenosyl-L-methionine (1,4-butanedisulfonate)

S-Adenosyl-L-methionine (1,4-butanedisulfonate)  (Synonyms: S-Adenosyl methionine (1,4-butanedisulfonate); Ademetionine (1,4-butanedisulfonate); AdoMet (1,4-butanedisulfonate))

目录号: HY-B0617B
产品使用指南

摩尔计算器

S-Adenosyl-L-methionine (S-Adenosyl methionine) 1,4-butanedisulfonate 是一种具有口服活性的甲基供体。S-Adenosyl-L-methionine 1,4-butanedisulfonate 是一种具有有效的抗抑郁和减轻疼痛作用的膳食补充剂。S-Adenosyl-L-methionine 1,4-butanedisulfonate 在癌症中还具有抗增殖、促凋亡和抗转移作用。S-Adenosyl-L-methionine 1,4-butanedisulfonate 可用于肝病和骨关节炎的研究。

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S-Adenosyl-L-methionine (1,4-butanedisulfonate) Chemical Structure

S-Adenosyl-L-methionine (1,4-butanedisulfonate) Chemical Structure

CAS No. : 200393-05-1

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S-Adenosyl-L-methionine (1,4-butanedisulfonate) 的其他形式现货产品:

S-Adenosyl-L-methionine (1,4-butanedisulfonate) 相关抗体

Top Publications Citing Use of Products

    S-Adenosyl-L-methionine (1,4-butanedisulfonate) purchased from MCE. Usage Cited in: Int Immunopharmacol. 2021 Mar 22;95:107545.  [Abstract]

    S-adenosylmethionine (SAMe) application at 30 min prior to high glucose treatment significantly increased H2S levels compared with the HG group. The cystathionine-β-synthase (CBS) level is obviously elevated in HG + SAMe group compared with the HG group.

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    S-Adenosyl-L-methionine (S-Adenosyl methionine) 1,4-butanedisulfonate is an orally active methyl group donor. S-Adenosyl-L-methionine 1,4-butanedisulfonate is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine 1,4-butanedisulfonate also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine 1,4-butanedisulfonate has the potential for, cancer, liver disease and osteoarthritis research[1][2][3].

    体外研究
    (In Vitro)

    S-Adenosyl-L-methionine (300 µM, 24 或 48 h) 1,4-butanedisulfonate 诱导细胞凋亡，并促进 Cal-33 和 JHU-SCC-011 细胞的细胞周期停滞[4]。 S-Adenosyl-L-methionine (300 µM, 24 h) 1,4-butanedisulfonate 减少 Cal-33 和 JHU-SCC-011 细胞的迁移[4]。 S-Adenosyl-L-methionine (5-40 μg/mL, 48 h) 1,4-butanedisulfonate 通过调节 DNMTs 的表达保护 5‑FU 的抗癌作用[5]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    S-Adenosyl-L-methionine (1,4-butanedisulfonate) 相关抗体:

    Apoptosis Analysis[4]

    Cell Line: Cal-33 and JHU-SCC-011 cells
    Concentration: 300 µM
    Incubation Time: 24 h (Cal-33) or 48 h (HU-SCC-011)
    Result: Showed an approximately 10% and 3%of apoptotic cells respectively.

    Cell Cycle Analysis[4]

    Cell Line: Cal-33 and JHU-SCC-011 cells
    Concentration: 300 µM
    Incubation Time: 24 h (Cal-33) or 48 h (HU-SCC-011)
    Result: Decreased the expression of cyclin B1, E1 and D1 in the Cal-33 and JHU-SCC-011 cells.
    体内研究
    (In Vivo)

    S-Adenosyl-L-methionine (30 mg/kg，口服，持续 3 天) 1,4-butanedisulfonate 可预防幼鼠出生后早期丙戊酸暴露引起的 ASD 样行为[6]。 S-Adenosyl-L-methionine (50 和 100 mg/kg，口服) 1,4-butanedisulfonate 在戊四唑诱导的大鼠癫痫模型中表现出抗癫痫、记忆增强和抗氧化特性[7]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Valproic acid treated young mice[6]
    Dosage: 30 mg/kg
    Administration: p.o., for 3 days
    Result: Alleviated most ASD like neurobehavioral symptoms.
    Normalized the redox potential in the prefrontal cortex.
    分子量

    616.69

    Formula

    C19H32N6O11S3
    CAS 号
    结构分类
    初始来源
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    S-Adenosyl-L-methionine (1,4-butanedisulfonate) 相关分类

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    S-Adenosyl-L-methionine (1,4-butanedisulfonate)200393-05-1S-Adenosyl methionine (1,4-butanedisulfonate) Ademetionine (1,4-butanedisulfonate) AdoMet (1,4-butanedisulfonate)Endogenous MetaboliteApoptosisInhibitorinhibitorinhibit

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