2. Metabolic Enzyme/Protease Apoptosis
  3. Endogenous Metabolite Apoptosis
  4. S-Adenosyl-L-methionine

S-Adenosyl-L-methionine  (Synonyms: S-腺苷-L-蛋氨酸; S-Adenosyl methionine; Ademetionine; AdoMet)

目录号: HY-B0617
COA 产品使用指南

摩尔计算器

S-Adenosyl-L-methionine (S-Adenosyl methionine) 是一种具有口服活性的甲基供体。S-Adenosyl-L-methionine 是一种具有有效的抗抑郁和减轻疼痛作用的膳食补充剂。S-Adenosyl-L-methionine 在癌症中还具有抗增殖、促凋亡和抗转移作用。S-Adenosyl-L-methionine 可用于肝病和骨关节炎的研究。

该游离形式化合物不稳定，推荐具有相同生物学活性的稳定盐形式 S-Adenosyl-L-methionine disulfate tosylate 和 S-Adenosyl-L-methionine tosylate。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

S-Adenosyl-L-methionine Chemical Structure

S-Adenosyl-L-methionine Chemical Structure

CAS No. : 29908-03-0

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

S-Adenosyl-L-methionine 的其他形式现货产品:

S-Adenosyl-L-methionine 相关抗体

Top Publications Citing Use of Products

    S-Adenosyl-L-methionine purchased from MCE. Usage Cited in: Int Immunopharmacol. 2021 Mar 22;95:107545.  [Abstract]

    S-adenosylmethionine (SAMe) application at 30 min prior to high glucose treatment significantly increased H2S levels compared with the HG group. The cystathionine-β-synthase (CBS) level is obviously elevated in HG + SAMe group compared with the HG group.

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    S-Adenosyl-L-methionine (S-Adenosyl methionine) is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research[1][2][3].

    IC50 & Target

    Human Endogenous Metabolite

     

    体外研究
    (In Vitro)

    S-Adenosyl-L-methionine (300 µM, 24 或 48 h) 诱导细胞凋亡，并促进 Cal-33 和 JHU-SCC-011 细胞的细胞周期停滞[4]。
    S-Adenosyl-L-methionine (300 µM, 24 h) 减少 Cal-33 和 JHU-SCC-011 细胞的迁移[4]。
    S-Adenosyl-L-methionine (5-40 μg/mL, 48 h) 通过调节 DNMTs 的表达保护 5‑FU 的抗癌作用[5]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    S-Adenosyl-L-methionine 相关抗体:

    Apoptosis Analysis[4]

    Cell Line: Cal-33 and JHU-SCC-011 cells
    Concentration: 300 µM
    Incubation Time: 24 h (Cal-33) or 48 h (HU-SCC-011)
    Result: Showed an approximately 10% and 3%of apoptotic cells respectively.

    Cell Cycle Analysis[4]

    Cell Line: Cal-33 and JHU-SCC-011 cells
    Concentration: 300 µM
    Incubation Time: 24 h (Cal-33) or 48 h (HU-SCC-011)
    Result: Decreased the expression of cyclin B1, E1 and D1 in the Cal-33 and JHU-SCC-011 cells.
    体内研究
    (In Vivo)

    S-Adenosyl-L-methionine (30 mg/kg，口服，持续 3 天) 可预防幼鼠出生后早期丙戊酸暴露引起的 ASD 样行为[6]。
    S-Adenosyl-L-methionine (50 和 100 mg/kg，口服) 在戊四唑诱导的大鼠癫痫模型中表现出抗癫痫、记忆增强和抗氧化特性[7]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Valproic acid treated young mice[6]
    Dosage: 30 mg/kg
    Administration: p.o., for 3 days
    Result: Alleviated most ASD like neurobehavioral symptoms.
    Normalized the redox potential in the prefrontal cortex.
    Clinical Trial
    分子量

    398.44

    Formula

    C15H22N6O5S
    CAS 号
    性状

    固体

    颜色

    Off-white to light yellow

    中文名称

    S-腺苷-L-蛋氨酸
    初始来源

    Escherichia coli
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    4°C, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

    溶解性数据
    细胞实验： 

    DMSO 中的溶解度 : 100 mg/mL (250.98 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    H2O 中的溶解度 : ≥ 43 mg/mL (107.92 mM)

    * "≥" means soluble, but saturation unknown.

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 2.5098 mL 12.5489 mL 25.0979 mL
    5 mM 0.5020 mL 2.5098 mL 5.0196 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
    您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
    纯度 & 产品资料

    纯度: ≥98.0%

    COA (289 KB)

    产品使用指南 (1538 KB)
    参考文献

    S-Adenosyl-L-methionine 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 2.5098 mL 12.5489 mL 25.0979 mL 62.7447 mL
    5 mM 0.5020 mL 2.5098 mL 5.0196 mL 12.5489 mL
    10 mM 0.2510 mL 1.2549 mL 2.5098 mL 6.2745 mL
    15 mM 0.1673 mL 0.8366 mL 1.6732 mL 4.1830 mL
    20 mM 0.1255 mL 0.6274 mL 1.2549 mL 3.1372 mL
    25 mM 0.1004 mL 0.5020 mL 1.0039 mL 2.5098 mL
    30 mM 0.0837 mL 0.4183 mL 0.8366 mL 2.0915 mL
    40 mM 0.0627 mL 0.3137 mL 0.6274 mL 1.5686 mL
    50 mM 0.0502 mL 0.2510 mL 0.5020 mL 1.2549 mL
    60 mM 0.0418 mL 0.2091 mL 0.4183 mL 1.0457 mL
    80 mM 0.0314 mL 0.1569 mL 0.3137 mL 0.7843 mL
    100 mM 0.0251 mL 0.1255 mL 0.2510 mL 0.6274 mL

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    S-Adenosyl-L-methionine29908-03-0S-Adenosyl methionine Ademetionine AdoMetS-腺苷-L-蛋氨酸Endogenous MetaboliteApoptosisATPmethioninedietarysupplementadenosyltransferasemethyl antidepressantanalgesicosteoarthritisliverInhibitorinhibitorinhibit

    您最近查看的产品:

    Your information is safe with us. * Required Fields.

       产品名称：

    		  

    * 需求量：

    * 客户姓名：

    		 

    * Email：

    * 电话：

    		 

    * 公司或机构名称：

       留言给我们：

    Bulk Inquiry

    Inquiry Information

    产品名称：
    S-Adenosyl-L-methionine
    目录号：
    HY-B0617
    需求量：

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

       产品名称：

    		  

    * Lot #：

    * 客户姓名：

    		 

    * Email：

       电话：

    		 

    * 部门：

    * 公司或机构名称：

    		 

       留言给我们：

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.

    嗨！很高兴为您提供帮助！

    尊敬的 MCE 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z