2. Cell Cycle/DNA Damage Anti-infection
  3. DNA/RNA Synthesis Parasite
  4. S-MGB-234

S-MGB-234 是一种用于非洲动物锥虫病 (AAT) 的小沟粘合剂。S-MGB-234 对 AAT 的主要致病菌：Trypanosoma congolense 和 Trypanosoma vivax 表现出优异的体外活性。S-MGB-234 与当前的二脒类活性分子没有交叉耐药性，并且不通过二脒类使用的转运蛋白内化。

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S-MGB-234 Chemical Structure

S-MGB-234 Chemical Structure

CAS No. : 1970223-53-0

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Other Forms of S-MGB-234:

S-MGB-234 相关抗体

Top Publications Citing Use of Products

查看 Parasite 亚型特异性产品:

查看所有亚型
Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

S-MGB-234 is a minor groove binder of Animal African Trypanosomiasis (AAT). S-MGB-234 displays excellent in vitro activities against the principal causative organisms of AAT; Trypanosoma congolense, and Trypanosoma vivax. S-MGB-234 does not show cross-resistance with the current diamidine agents and are not internalized via the transporters used by diamidines[1].

IC50 & Target

Trypanosoma

 

体外研究
(In Vitro)

S-MGB-234 (compound 7) (69 hours) shows nontoxic to L6 cells with an EC50 of 20.39 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

S-MGB-234 相关抗体:
体内研究
(In Vivo)

S-MGB-234 (compound 7) provides total cure and no relapses in mice (cured/infected, 4/4), when treated with 2 applications of 50 mg/kg i.p.. Partial cure (1/4) is seen in mice treated with four daily applications of 10 mg/kg i.p., whilst only two applications of S-MGB-234 (compound 7) at 10 mg/kg i.p. gives no cure but prolongs survival relative to the untreated control[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

568.63

Formula

C30H32N8O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

S-MGB-234 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S-MGB-2341970223-53-0DNA/RNA SynthesisParasiteminor groove binderAnimal African TrypanosomiasisAATcross-resistancediamidineInhibitorinhibitorinhibit

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产品名称：
S-MGB-234
目录号：
HY-145287
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