2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor nAChR iGluR
  4. (S)-Norzopiclone

(S)-Norzopiclone  (Synonyms: (S)-N-Desmethyl zopiclone; SEP-174559)

目录号: HY-U00199A
产品使用指南 技术支持

(S)-Norzopiclone ((S)-N-Desmethyl zopiclone; SEP-174559) 是 Zopiclone 的代谢物，具有抗焦虑和抗惊厥作用。(S)-Norzopiclone 对 GABAA 受体的含 γ2 亚型具有苯二氮卓样作用，并抑制 nACh 和 NMDA 受体。

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(S)-Norzopiclone Chemical Structure

(S)-Norzopiclone Chemical Structure

CAS No. : 151776-26-0

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Other Forms of (S)-Norzopiclone:

(S)-Norzopiclone 相关抗体

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AMPA Receptor NMDA Receptor Kainate Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(S)-Norzopiclone ((S)-N-Desmethyl zopiclone; SEP-174559) is a metabolite of Zopiclone with anxiolytic and anticonvulsant effects. (S)-Norzopiclone has benzodiazepine-like actions at γ2-bearing subtypes of the GABAA receptor and inhibits nACh and NMDA receptors[1].

体外研究
(In Vitro)

Micromolar concentrations of (S)-Norzopiclone (SEP-174559) potentiates GABAA receptor currents evoked by subsaturating concentrations of GABA[1].
(S)-Norzopiclone9 is not selective between alpha1-, alpha2-, or alpha3-bearing GABAA receptors. Within the nicotinic receptor superfamily, (S)-Norzopiclone does not affect serotonin type-3 receptor function but is found to inhibit nACh receptors[1].
In the glutamate receptor superfamily, (S)-Norzopiclone inhibits N-methyl-D-aspartate (NMDA) receptor currents but does not affect non-NMDA receptors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(S)-Norzopiclone 相关抗体:
分子量

374.78

Formula

C16H15ClN6O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(S)-Norzopiclone 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

(S)-Norzopiclone151776-26-0(S)-N-Desmethyl zopiclone SEP-174559SEP174559SEP 174559SEP-174559GABA ReceptornAChRiGluRGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorNicotinic acetylcholine receptorsIonotropic glutamate receptorsGABAANMDAnAChbenzodiazepineanxiolyticanticonvulsantZopicloneInhibitorinhibitorinhibit

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