2. GPCR/G Protein
  3. Bradykinin Receptor
  4. Safotibant

Safotibant  (Synonyms: LF22-0542)

目录号: HY-100827
产品使用指南

摩尔计算器

Safotibant (LF22-0542) 是激肽 B1 受体 (BKB1R) 的选择性拮抗剂，对人源和鼠源 BKB1R 的 Ki 分别为 0.35 和 6.5 nM。Safotibant 在小鼠模型中表现出镇痛和抗炎活性。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Safotibant Chemical Structure

Safotibant Chemical Structure

CAS No. : 633698-99-4

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Safotibant 相关抗体

Top Publications Citing Use of Products

查看 Bradykinin Receptor 亚型特异性产品:

查看所有亚型
Bradykinin B1 Receptor (B1R) Bradykinin B2 Receptor (B2R)

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Safotibant (LF22-0542) is a selective antagonist for kinin B1 receptor (BKB1R), with Ki of 0.35 and 6.5 nM, for human and mouse BKB1R, respectively. Safotibant exhibits analgesic and anti-inflammatory property in mice model[1][2].

体内研究
(In Vivo)

Safotibant (10 mg/kg，皮下注射，每天 3 次，持续 8 天) 在 C3H/HeJ 小鼠溶骨性肉瘤异种移植模型中，对骨癌引发的疼痛具有镇痛活性，且不影响疾病进程[1]。
Safotibant (一滴滴眼液，每天两次，持续 7 天) 在 streptozotocin (STZ) 诱导的大鼠糖尿病模型中，抑制炎症介质 B1R、iNOS、IL-1β、COX-2、VEGF-R2 和 HIF-1α 的表达，减轻糖尿病引发的视网膜炎症和氧化应激反应[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Osteolytic sarcoma xenograft C3H/HeJ mice model[1]
Dosage: 10 mg/kg
Administration: s.c., 3 times a day for 8 days
Result: Decreased numbers of flinching and time spent on spontaneous guarding.
Animal Model: Streptozotocin (STZ)-diabetic Wistar rats model[2]
Dosage: One eye drop
Administration: On eyes application, twice a day for 7 days
Result: Reversed retinal vascular hyperpermeability, decreased levels of retinal leukostasis and superoxide anion in 3 retinal nuclear layers.
分子量

502.63

Formula

C25H34N4O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Safotibant 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Safotibant633698-99-4LF22-0542Bradykinin ReceptorWistar ratC3H/HeJ miceanalgesicselectiveInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Safotibant
目录号：
HY-100827
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z