2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. Salvinorin A

Salvinorin A 是一种有效，独特且短效的高效 kappa-opioid receptor(KOPr) 激动剂，Ki 值为 4.3 nM。 Salvinorin A 是可从丹参中分离出的一种非氮新环戊烷。

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Salvinorin A Chemical Structure

Salvinorin A Chemical Structure

CAS No. : 83729-01-5

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规格 价格 是否有货 数量
1 mg ￥2970
3 - 4 周
5 mg   询价  
10 mg   询价  

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Salvinorin A 相关抗体

Top Publications Citing Use of Products

查看 Opioid Receptor 亚型特异性产品:

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Salvinorin A is a potent, unique and short-acting high efficacy kappa-opioid receptor (KOPr) agonist with Ki value of 4.3 nm. Salvinorin A is a non-nitrogenous neoclerodane isolated from Salvia divinorum.

IC50 & Target

Ki:4.3 nm (kappa-opioid receptor)[1]
体外研究
(In Vitro)

Salvinorin A (Divinorin A)(0.01-10 pM; pre-30 minues; 24 hours) does not affect the membrane function after 24-h exposure in macrophages[1].
Salvinorin A (Divinorin A) (0.01-10 pM; pre-30 minues; 18 hours) before LPS stimulation causes a significant and concentrationdependent manner reduction of LPS-stimulated nitrite levels, the IC50 (95% CL) of salvinorin A inhibitory effect was 6.5×10−13M[1].
Salvinorin A (Divinorin A) (0.01-10 pM; pre-30 minues; 18 hours) incubates 30 min before LPS stimulation, reduces in concentration-dependent manner the LPSinduced iNOS, but not COX-2, hyperexpression, reaching a statistical significance at the 10 pM concentration[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Salvinorin A 相关抗体:
体内研究
(In Vivo)

Salvinorin A (intraperitoneal injection; 0.5-2 mg/kg; pre-treatment 30 minutes) at the 0.5 mg/kg dose is the most effective one, at the dose of 0.5 mg/kg, significantly inhibits oedema during the first 6 h; at the dose of 1 mg/kg, salvinorin A significantly reduces the oedema only 4 h after carrageenan injection; at the highest doses tested (2 mg/kg), salvinorin A fails to evoke significant changes on the carrageenan-induced paw oedema[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

432.46

Formula

C23H28O8
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥98.0%

COA (294 KB)

产品使用指南 (1538 KB)
参考文献

Salvinorin A 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Salvinorin A83729-01-5Divinorin AOpioid ReceptorhallucinogenKOPrpawoedemaInhibitorinhibitorinhibit

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目录号：
HY-100845
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