2. Anti-infection
  3. Antibiotic Bacterial
  4. Sancycline hydrochloride

Sancycline hydrochloride  (Synonyms: Bonomycin hydrochloride; 6-Demethyl-6-deoxytetracycline hydrochloride)

目录号: HY-17466A
产品使用指南

摩尔计算器

Sancycline (6-Demethyl-6-deoxytetracycline) hydrochloride 与 30 S 核糖体亚基 (30 S ribosomal subunit) 可逆结合，并通过阻断氨基酰基 tRNA 进入核糖体 A 位点来抑制蛋白质翻译，与四环素 (HY-A0107) 类似。Sancycline hydrochloride, 由四个线性融合的 6 元环和 4 个立体中心组成，是由 Declomycin 的氯和苄羟基基团经过氢热解制得的一种半合成四环素 (HY-A0107)。

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Sancycline hydrochloride Chemical Structure

Sancycline hydrochloride Chemical Structure

CAS No. : 6625-20-3

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规格 价格 是否有货
5 mg ￥2550
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Sancycline hydrochloride 的其他形式现货产品:

Customer Review

Other Forms of Sancycline hydrochloride:

Sancycline hydrochloride 相关抗体

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sancycline (6-Demethyl-6-deoxytetracycline) hydrochloride acts by reversibly binding to the 30 S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome a site similar to tetracycline (HY-A0107). Sancycline hydrochloride, four linearly fused six-membered rings with four stereocenters, is a rare semi-synthetic tetracycline (HY-A0107) prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of Declomycin[1][2][3].

IC50 & Target

Tetracycline

 

体外研究
(In Vitro)

Sancycline hydrochloride (400 μM, 24 小时) 降低 2 氯乙基硫醚 (CEES) 和氮芥 (NM) 诱导的角膜损伤，并在一定程度上抑制基质金属蛋白酶 (MMP)-9 在基底膜区 (BMZ) 的表达[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sancycline hydrochloride 相关抗体:

Immunofluorescence[2]

Cell Line: Frozen corneal sections
Concentration: 400 μM
Incubation Time: 24 h
Result: lnhibited MMP-9 expression to some degree in the NM-exposed corneas.
分子量

450.87

Formula

C21H23ClN2O7
CAS 号
性状

固体

颜色

White to off-white

中文名称

山环素盐酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Sancycline hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sancycline6625-20-3Bonomycin6-Demethyl-6-deoxytetracycline山环素盐酸盐AntibioticBacterialsix-membered ringshydrogenolysis30 S ribosomal subunitblock protein translationInhibitorinhibitorinhibit

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