2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. Sandaracopimaric acid

Sandaracopimaric acid  (Synonyms: 山达海松酸)

目录号: HY-133594 纯度: 98.86%
COA 产品使用指南

摩尔计算器

Sandaracopimaric acid 是一种具有抗炎作用的二萜类化合物，可减少苯肾上腺素引起的肺动脉收缩，EC50 为 43.93 μM。

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Sandaracopimaric acid Chemical Structure

Sandaracopimaric acid Chemical Structure

CAS No. : 471-74-9

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规格 价格 是否有货 数量
1 mg ￥6120
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Sandaracopimaric acid 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sandaracopimaric acid is a diterpenoid with anti-inflammatory effect. Sandaracopimaric acid reduces the contraction of phenylephrine-induced pulmonary arteries with an EC50 of 43.93 μM[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
> 40 μM
Compound: 11
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
[PMID: 23691952]
HL-60 IC50
> 40 μM
Compound: 11
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
[PMID: 23691952]
MCF7 IC50
> 40 μM
Compound: 11
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 23691952]
Oocyte EC50
24.9 μM
Compound: 5
Allosteric modulation of gamma-aminobutyric acid receptor A alpha1beta3gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis
Allosteric modulation of gamma-aminobutyric acid receptor A alpha1beta3gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis
[PMID: 21793559]
Oocyte EC50
31.2 μM
Compound: 5
Allosteric modulation of gamma-aminobutyric acid receptor A alpha2beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis
Allosteric modulation of gamma-aminobutyric acid receptor A alpha2beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis
[PMID: 21793559]
Oocyte EC50
33.3 μM
Compound: 5
Allosteric modulation of gamma-aminobutyric acid receptor A alpha1beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis
Allosteric modulation of gamma-aminobutyric acid receptor A alpha1beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis
[PMID: 21793559]
Oocyte EC50
40.7 μM
Compound: 5
Allosteric modulation of gamma-aminobutyric acid receptor A alpha5beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis relative to control
Allosteric modulation of gamma-aminobutyric acid receptor A alpha5beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis relative to control
[PMID: 21793559]
Oocyte EC50
48.1 μM
Compound: 5
Allosteric modulation of gamma-aminobutyric acid receptor A alpha1beta1gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis
Allosteric modulation of gamma-aminobutyric acid receptor A alpha1beta1gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis
[PMID: 21793559]
Oocyte EC50
56.6 μM
Compound: 5
Allosteric modulation of gamma-aminobutyric acid receptor A alpha3beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis
Allosteric modulation of gamma-aminobutyric acid receptor A alpha3beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis
[PMID: 21793559]
SMMC-7721 IC50
> 40 μM
Compound: 11
Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay
Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay
[PMID: 23691952]
SW480 IC50
> 40 μM
Compound: 11
Cytotoxicity against human SW480 cells after 48 hrs by MTT assay
Cytotoxicity against human SW480 cells after 48 hrs by MTT assay
[PMID: 23691952]
分子量

302.45

Formula

C20H30O2
CAS 号
性状

固体

颜色

White to off-white

中文名称

山达海松酸
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 3.5 mg/mL (11.57 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.3063 mL 16.5317 mL 33.0633 mL
5 mM 0.6613 mL 3.3063 mL 6.6127 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Sandaracopimaric acid 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3063 mL 16.5317 mL 33.0633 mL 82.6583 mL
5 mM 0.6613 mL 3.3063 mL 6.6127 mL 16.5317 mL
10 mM 0.3306 mL 1.6532 mL 3.3063 mL 8.2658 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sandaracopimaric acid471-74-9山达海松酸GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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产品名称：
Sandaracopimaric acid
目录号：
HY-133594
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