2. NF-κB
  3. Keap1-Nrf2
  4. Santamarine

Santamarine  (Synonyms: Santamarin; Balchanin)

目录号: HY-N1326
产品使用指南

摩尔计算器

Santamarine (Santamarin) 是一种倍半萜内酯，通过 Nrf2 易位增加 HO-1 的表达，并通过抑制 LPS 诱导的巨噬细胞中的 NF-κB 易位抑制 NO、PGE2、TNF-α 和 IL-1β 的产生。Santamarine 通过抑制 UVA 照射的人皮肤成纤维细胞 (HDFs) 中的 MAPK/AP-1 和刺激 TGF-β/Smad 信号而显示抗光老化特性。具有抗氧化活性。

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Santamarine Chemical Structure

Santamarine Chemical Structure

CAS No. : 4290-13-5

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Santamarine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Santamarine (Santamarin), a sesquiterpene lactone, increases HO-1 expression through Nrf2 translocation and suppresses NO, PGE2, TNF-α, and IL-1β production through inhibition of NF-κB translocation in LPS-induced macrophages. Santamarine shows anti-photoaging properties via inhibition of MAPK/AP-1 and stimulation of TGF-β/Smad signaling in UVA-irradiated human dermal fibroblasts (HDFs). Antioxidant activities[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CCRF-CEM IC50
0.16 μg/mL
Compound: 1; STM
Growth inhibition of human CCRF-CEM cells incubated for 24 to 48 hrs by trypan blue exclusion assay
Growth inhibition of human CCRF-CEM cells incubated for 24 to 48 hrs by trypan blue exclusion assay
[PMID: 33775837]
KB IC50
0.16 μg/mL
Compound: 1; STM
Growth inhibition of human KB cells incubated for 72 hrs by methylene blue staining based assay
Growth inhibition of human KB cells incubated for 72 hrs by methylene blue staining based assay
[PMID: 33775837]
L1210 IC50
0.16 μg/mL
Compound: 1; STM
Growth inhibition of mouse L1210 cells incubated for 24 to 48 hrs by trypan blue exclusion assay
Growth inhibition of mouse L1210 cells incubated for 24 to 48 hrs by trypan blue exclusion assay
[PMID: 33775837]
LS174T IC50
0.16 μg/mL
Compound: 1; STM
Growth inhibition of human LS174T cells incubated for 72 hrs by methylene blue staining based assay
Growth inhibition of human LS174T cells incubated for 72 hrs by methylene blue staining based assay
[PMID: 33775837]
LX-2 IC50
> 60 μM
Compound: 1; STM
Inhibition of hyaluronic acid deposition in human LX2 cells incubated for 72 hrs by ELISA
Inhibition of hyaluronic acid deposition in human LX2 cells incubated for 72 hrs by ELISA
[PMID: 33775837]
LX-2 IC50
16.5 μM
Compound: 1; STM
Cytotoxicity against human LX2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human LX2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 33775837]
LX-2 IC50
18.6 μM
Compound: 1; STM
Inhibition of laminin deposition in human LX2 cells incubated for 72 hrs by ELISA
Inhibition of laminin deposition in human LX2 cells incubated for 72 hrs by ELISA
[PMID: 33775837]
LX-2 IC50
7.3 μM
Compound: 1; STM
Inhibition of collagen type 1 deposition in human LX2 cells incubated for 72 hrs by ELISA
Inhibition of collagen type 1 deposition in human LX2 cells incubated for 72 hrs by ELISA
[PMID: 33775837]
MCF7 IC50
0.16 μg/mL
Compound: 1; STM
Growth inhibition of human MCF7 cells incubated for 72 hrs by methylene blue staining based assay
Growth inhibition of human MCF7 cells incubated for 72 hrs by methylene blue staining based assay
[PMID: 33775837]
Platelet IC50
84.93 μM
Compound: Santamarin
Antimigraine activity in bovine citreated platelet assessed as inhibition of [14C]serotonin release after 6 mins by scintillation counting
Antimigraine activity in bovine citreated platelet assessed as inhibition of [14C]serotonin release after 6 mins by scintillation counting
[PMID: 1431933]
T-cell IC50
19.6 μM
Compound: 7
Immunosuppressant activity in human T lymphocytes assessed as inhibition of anti-human CD3 and anti-human CD28 monoclonal antibody-induced T lymphocyte proliferation incubated for 72 hrs by FACS analysis
Immunosuppressant activity in human T lymphocytes assessed as inhibition of anti-human CD3 and anti-human CD28 monoclonal antibody-induced T lymphocyte proliferation incubated for 72 hrs by FACS analysis
[PMID: 31181920]
分子量

248.32

Formula

C15H20O3
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Santamarine 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Santamarine4290-13-5Santamarin BalchaninKeap1-Nrf2anti-photoaginginflammatory responsesheme oxygenase-1human dermal fibroblastsantioxidantInhibitorinhibitorinhibit

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