2. Metabolic Enzyme/Protease
  3. MAGL
  4. SAR629

SAR629 是一种有效的甘油单酯脂肪酶 (MGL) 共价抑制剂。SAR629 还抑制 2-Arachidonoylglycerol (2-AG) 降解。

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SAR629 Chemical Structure

SAR629 Chemical Structure

CAS No. : 1221418-42-3

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SAR629 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SAR629 is a potent monoglyceride lipase (MGL) covalent inhibitor. SAR629 also inhibits 2-Arachidonoylglycerol (2-AG) degradation[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
COS-7 IC50
282 nM
Compound: SAR629
Inhibition of human recombinant FAAH expressed in COS7 cells using anandamide as substrate
Inhibition of human recombinant FAAH expressed in COS7 cells using anandamide as substrate
[PMID: 25282655]
HEK293 IC50
0.9 nM
Compound: SAR629
Inhibition of human recombinant MAGL expressed in HEK293 cells using 2-AG as substrate
Inhibition of human recombinant MAGL expressed in HEK293 cells using 2-AG as substrate
[PMID: 25282655]
体外研究
(In Vitro)

SAR629 is a potent dual inhibitory action on MAGL and fatty acid amide hydrolase (FAAH). SAR629 inhibits rodent monoglyceride lipase (MGL) activity at subnanomolar potencies (IC50 values of 1.1 nM and 219 pM in rat and mouse brain membranes, respectively)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SAR629 相关抗体:
分子量

383.39

Formula

C20H19F2N5O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SAR629 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SAR6291221418-42-3SAR 629SAR-629MAGLMonoacylglycerol lipasemonoglyceridelipaseMGLFAAHInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-118653
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