2. Anti-infection
  3. SARS-CoV
  4. SARS-CoV-2-IN-15

SARS-CoV-2-IN-15 (compound 11) 是一种有效的 SARS-CoV-2 抑制剂，IC50 为 0.49 μM。SARS-CoV-2-IN-15 是一种氯硝柳胺类似物。SARS-CoV-2-IN-15 在人血浆和肝 S9 酶测定中比氯硝柳胺具有更高的稳定性，口服给药可提高生物利用度和半衰期。

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SARS-CoV-2-IN-15 Chemical Structure

SARS-CoV-2-IN-15 Chemical Structure

CAS No. : 1580-42-3

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SARS-CoV-2-IN-15 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SARS-CoV-2-IN-15 (compound 11) is a potent inhibitor of SARS-CoV-2 with an IC50 of 0.49 μM. SARS-CoV-2-IN-15 is a niclosamide analogue. SARS-CoV-2-IN-15 contains higher stability in human plasma and liver S9 enzymes assay than niclosamide, which can improve bioavailability and half-life when administered orally[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
0.89 μM
Compound: 11
Inhibition of Wnt/beta-catenin in HEK293 cells assessed as inhibition of Wnt3A-stimulated TOPFlash activity after 8 hrs
Inhibition of Wnt/beta-catenin in HEK293 cells assessed as inhibition of Wnt3A-stimulated TOPFlash activity after 8 hrs
[PMID: 26272032]
Macrophage IC50
5.9 μM
Compound: 27
Cytotoxicity against mouse macrophage cell line J774.1 (ATCC TIB-67) for 3 days by Alamar Blue
Cytotoxicity against mouse macrophage cell line J774.1 (ATCC TIB-67) for 3 days by Alamar Blue
[PMID: 23211970]
Vero C1008 CC50
100 μM
Compound: 11
Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability preincubated for 2 hrs followed by SARS-CoV-2 addition measured after 24 hrs by CPE assay
Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability preincubated for 2 hrs followed by SARS-CoV-2 addition measured after 24 hrs by CPE assay
[PMID: 35344901]
Vero C1008 CC50
5.95 μM
Compound: 11
Cytotoxicity against African Green monkey Vero E6 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against African Green monkey Vero E6 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 35344901]
分子量

315.67

Formula

C14H9ClF3NO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SARS-CoV-2-IN-15 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SARS-CoV-2-IN-151580-42-3SARS-CoVSARS coronavirusSARS-CoV-2niclosamide analoguebioavailabilityhalf-lifeorallyInhibitorinhibitorinhibit

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目录号：
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