2. Anti-infection
  3. SARS-CoV
  4. SARS-CoV MPro-IN-1

SARS-CoV MPro-IN-1 是 SARS-CoV-2 3CLpro 共价抑制剂，IC50 为 40 nM。SARS-CoV MPro-IN-1 在细胞培养中表现出良好的抗 SARS-CoV-2 感染活性，EC50 为 0.33 μM，具有研究 COVID-19 的潜力。

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SARS-CoV MPro-IN-1 Chemical Structure

SARS-CoV MPro-IN-1 Chemical Structure

CAS No. : 2413716-71-7

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规格 价格 是否有货 数量
1 mg ￥1706
3 - 4 周
5 mg   询价  
10 mg   询价  

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Customer Review

SARS-CoV MPro-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SARS-CoV MPro-IN-1 is a SARS-CoV-2 3CLpro covalent inhibitor, with an IC50 of 40 nM. SARS-CoV MPro-IN-1 shows good anti-SARS-CoV-2-infection activity in cell culture with an EC50 of 0.33 μM. SARS-CoV MPro-IN-1 has the potential for COVID-19 research[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Vero C1008 CC50
> 100 μM
Compound: 11b
Cytotoxicity against African green monkey Vero E6 cells assessed as cell growth inhibition incubated for 24 hrs by CCK8 assay
Cytotoxicity against African green monkey Vero E6 cells assessed as cell growth inhibition incubated for 24 hrs by CCK8 assay
[PMID: 32771797]
Vero C1008 CC50
> 100 μM
Compound: 22
Cytotoxicity against African green monkey Vero E6 cells by CCK-8 assay
Cytotoxicity against African green monkey Vero E6 cells by CCK-8 assay
[PMID: 33486200]
Vero C1008 CC50
> 100 μM
Compound: 6
Cytotoxicity against African green monkey Vero E6 cells by CCK-8 assay
Cytotoxicity against African green monkey Vero E6 cells by CCK-8 assay
[PMID: 33186044]
Vero C1008 CC50
> 100 μM
Compound: 92
Cytotoxicity against African green monkey Vero E6 cells assessed as reduction of cell viability by CellTiterGlo assay
Cytotoxicity against African green monkey Vero E6 cells assessed as reduction of cell viability by CellTiterGlo assay
[PMID: 34798775]
体内研究
(In Vivo)

SARS-CoV MPro-IN-1 (compound 11b) (5 mg/kg; intravenous drip administration) shows the t1/2 is <1.65 hours and the clearance rate is 20.6 mL/min/mg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

464.49

Formula

C25H25FN4O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SARS-CoV MPro-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SARS-CoV MPro-IN-12413716-71-7SARS-CoVSARS coronavirusInhibitorinhibitorinhibit

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目录号：
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