2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. SB-221284

SB 221284 是一种选择性 5-HT2C/2B 受体拮抗剂，5-HT2A, 5-HT2B 和 5-HT2C 受体的 pKi 值分别为 6.4, 7.9 和 8.6。SB 221284可用于神经系统疾病的研究.

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SB-221284 Chemical Structure

SB-221284 Chemical Structure

CAS No. : 196965-14-7

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SB-221284 相关抗体

Top Publications Citing Use of Products

查看 5-HT Receptor 亚型特异性产品:

查看所有亚型
5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SB 221284 is a selective 5-HT2C/2B receptor antagonist with pKi values are 6.4, 7.9 and 8.6 for 5-HT2A, 5-HT2B and 5-HT2C receptors, respectively. SB 221284 can be used for the research of neurological disease[1].

IC50 & Target[1]

5-HT2A Receptor

6.4 (pKi)

5-HT2B Receptor

7.9 (pKi)

5-HT2C Receptor

8.6 (pKi)

体内研究
(In Vivo)

SB 221284 (0.1~1 mg/kg, i.p.) pre-treatment doses shows to block mCPP induced hypolocomotion, significantly enhances the hyperactivity induced by phencyclidine or MK-801[1].
SB 221284 (1 mg/kg, i.p.) significantly enhances the magnitude and duration of the increase induced by phencyclidine[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague Dawley rats (250–360 g)[1]
Dosage: 0.1~1 mg/kg
Administration: I.p.
Result: Pre-treatment doses showed to block mCPP induced hypolocomotion, significantly enhanced the hyperactivity induced by phencyclidine or MK-801.
Animal Model: Male Sprague Dawley rats (250–360 g)[1]
Dosage: 1 mg/kg
Administration: I.p.
Result: Significantly enhanced the magnitude and duration of the increase induced by phencyclidine.
分子量

353.36

Formula

C16H14F3N3OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SB-221284 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SB-221284196965-14-7SB221284SB 2212845-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorselectiveneurologicalmCPPhypolocomotionhyperactivityInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-103155
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