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  4. SB 714786

SB 714786是一种强效、选择性的5-羟色胺1D（5-HT1D）受体拮抗剂。它是从之前报道的双重5-HT1选择性5-羟色胺再摄取抑制剂（5HT1-SSRIs）系列中发展而来的。SB 714786是首次报道的高效、选择性5-HT1D受体拮抗剂，为进一步理解5-HT1受体亚型的作用提供了极其有用的药理学工具。它对所有三种受体都没有或只有很低的内在活性。SB 714786对5-HT1A、5-HT1B、5-HT1D和SerT受体的pKi值分别为6.5、6.7、9.1和6.5，显示出对5-HT1D受体的高度选择性。这些特性使SB 714786成为研究5-HT1D受体功能和相关疾病抑制的潜在工具化合物。

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SB 714786 Chemical Structure

SB 714786 Chemical Structure

CAS No. : 584555-10-2

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SB 714786 相关抗体

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  • 生物活性

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生物活性

SB 714786 is a potent and selective 5-hydroxytryptamine 1D (5-HT1D) receptor antagonist. It was developed from the previously reported series of dual 5-HT1 selective 5-hydroxytryptamine reuptake inhibitors (5HT1-SSRIs). SB 714786 is the first reported highly potent and selective 5-HT1D receptor antagonist, providing an extremely useful pharmacological tool for further understanding the role of 5-HT1 receptor subtypes. It has no or very low intrinsic activity against all three receptors. SB 714786 has pKi values of 6.5, 6.7, 9.1 and 6.5 for 5-HT1A, 5-HT1B, 5-HT1D and SerT receptors, respectively, showing high selectivity for 5-HT1D receptors. These properties make SB 714786 a potential tool compound for studying the function of 5-HT1D receptors and the treatment of related diseases.

分子量

412.53

Formula

C26H28N4O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SB 714786 相关分类

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  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SB 714786584555-10-2SB714786SB-714786OthersInhibitorinhibitorinhibit

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