2. SBI-183

SBI-183 是一种具有口服活性的 QSOX1 抑制剂 (Kd: 20 μM)。SBI-183 可抑制肾癌细胞系、三阴性乳腺癌细胞系、肺腺癌细胞系和胰腺导管腺癌的增殖和侵袭表型。SBI-183 可体内抑制两种人肾细胞癌异种移植小鼠模型的肿瘤生长。

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SBI-183 Chemical Structure

SBI-183 Chemical Structure

CAS No. : 625403-59-0

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SBI-183 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SBI-183 is an orally active inhibitor of QSOX1 (Kd: 20 μM). SBI-183 suppresses the proliferative and invasive phenotype of renal cancer cell lines, including triple negative breast cancer cell line, lung adenocarcinoma cell line and pancreatic ductal adenocarcinoma. SBI-183 inhibits tumor growth in two human xenograft mouse models of renal cell carcinoma in vivo [1].

体外研究
(In Vitro)

SBI-183 (6.25-50 μmol/L, 15 min) 以剂量依赖性方式抑制 rQSOX1 的酶活[1]。
SBI-183 可抑制肿瘤细胞的增殖，但不会杀死成纤维细胞或快速增殖的 PBMC (0.625-20 μmol/L, 5 days)，抑制786-O、RCJ-41T2 和 MDA-MB-231的活力，IC50 分别为 4.6 μM、3.9 μM 和 2.4 μM (0.076 nM-40 μM, 72 h) [1]。
SBI-183 (2.5-20 μM, 4-8 天)对 786-O、RCJ-41T2、MDA-MB-231、A549 和 MIA PaCa2 的二维和三维模型的肿瘤侵袭有剂量依赖性抑制作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SBI-183 相关抗体:

Cell Proliferation Assay[1]

Cell Line: 786-O, RCJ-41T2, MDA-MB-231, A549 和 MIA PaCa2
Concentration: 0.625, 1.25, 2.5, 5, 10, 20 μM
Incubation Time: 5 days
Result: Inhibited the growth of each tumor cell in a concentration-dependent manner.

Cell Invasion Assay[1]

Cell Line: 786-O, RCJ-41T2, MDA-MB-231, A549 和 MIA PaCa2
Concentration: 2.5, 5, 10, 20 μM
Incubation Time: 4, 6, 8 days
Result: Reduced invasion through Matrigel in each cell line.
体内研究
(In Vivo)

SBI-183 (786-O: 400 μg/小鼠/天，口服，35 天; RCJ-41T2: 100 mg/kg，口服，21 天) 可分别抑制两种肾细胞癌人异种移植小鼠模型的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Human xenograft mouse models of renal cell carcinoma (786-O and RCJ-41T2)[1]
Dosage: 400 μg/mouse/day (786-O); 100 mg/kg (RCJ-41T2)
Administration: Oral gavage (p.o.)
Result: Inhibited the growth of 786-O and RCJ-41T2 in vivo.
Reduced laminin-α4 deposition in RCJ-41T2 mouse xenografts.
分子量

296.36

Formula

C18H20N2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SBI-183 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SBI-183625403-59-0SBI183SBI 183Breast cancer786-OMDA-MB-231A549MIA PaCa2Invasionrenal cell carcinomaInhibitorinhibitorinhibit

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