Ecopipam hydrobromide  (Synonyms: SCH 39166 hydrobromide)

Ecopipam (SCH 39166) hydrobromide is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with K_is of 1.2 nM and 2.0 nM, respectively. Ecopipam hydrobromide shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor (K_i=0.98, 5.52, 0.08, and 0.73 μM, respectively). Ecopipam hydrobromide can be used for the research of schizophrenia and obesity^[1].

Ecopipam (2 μM) hydrobromide 完全消除多巴胺 (10 μM) 在孤立的皮质海马结构中的促惊厥作用^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ecopipam hydrobromide (10，mg/kg，口服) 拮抗大鼠中 Apomorphine 诱导的刻板印象^[4]。
Ecopipam hydrobromide (5 和 10 μM，灌注，1 μL/分钟) 可逆地和剂量依赖性地减少大鼠纹状体中乙酰胆碱的释放^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

394.73

C₁₉H₂₁BrClNO

2587360-22-1

固体

White to off-white

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Wu WL, et al. Dopamine D1/D5 receptor antagonists with improved pharmacokinetics: design, synthesis, and biological evaluation of phenol bioisosteric analogues of benzazepine D1/D5 antagonists. J Med Chem. 2005 Feb 10;48(3):680-93.  [Content Brief]

  [2]. Sharopov S, et al. Dopaminergic modulation of low-Mg²⁺-induced epileptiform activity in the intact hippocampus of the newborn mouse in vitro. J Neurosci Res. 2012 Oct;90(10):2020-33.  [Content Brief]

  [3]. Satanove DJ, et al. Nicotine-induced enhancement of a sensory reinforcer in adult rats: antagonist pretreatment effects. Psychopharmacology (Berl). 2021 Feb;238(2):475-486.  [Content Brief]

  [4]. R E Chipkin, et al. Pharmacological profile of SCH39166: a dopamine D1 selective benzonaphthazepine with potential antipsychotic activity. J Pharmacol Exp Ther. 1988 Dec;247(3):1093-102.  [Content Brief]

  [5]. E Acquas, et al. Local application of SCH 39166 reversibly and dose-dependently decreases acetylcholine release in the rat striatum. Eur J Pharmacol. 1999 Nov 3;383(3):275-9.  [Content Brief]