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  4. SCH 900229

SCH 900229是一种强效的γ-分泌酶抑制剂，具有选择性针对PS1的活性。SCH 900229的Aβ40 IC50值为1.3 nM，显示出其在降低Aβ方面的优秀能力。SCH 900229在预临床动物模型中经过口服给药后表现出良好的Aβ降低效果。SCH 900229已被推进至人类临床试验，以进一步开发用于抑制阿尔茨海默病的化合物。

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SCH 900229 Chemical Structure

SCH 900229 Chemical Structure

CAS No. : 1100361-36-1

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SCH 900229 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SCH 900229 is a potent γ-secretase inhibitor with selective activity against PS1. The Aβ40 IC50 value of SCH 900229 is 1.3 nM, showing its excellent ability in reducing Aβ. SCH 900229 has shown good Aβ-lowering effects after oral administration in preclinical animal models. SCH 900229 has been advanced to human clinical trials for further development of compounds for the inhibition of Alzheimer's disease[1].

分子量

506.97

Formula

C21H21ClF2O6S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SCH 900229 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SCH 9002291100361-36-1SCH900229SCH-900229OthersInhibitorinhibitorinhibit

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