Nav1.7 ion channel

Pathways Recommended:	Membrane Transporter/Ion Channel

By Targets:	Calcium Channel (1) Sodium Channel (2) Apoptosis (2) Interleukin Related (2) NF-κB (2) p38 MAPK (2) TNF Receptor (2)
By Research Areas:	Cancer (2) Inflammation/Immunology (2) Neurological Disease (3)

Targets Recommended: Chloride Channel Calcium Channel HCN Channel CRAC Channel Piezo Channel TRP Channel Sodium Channel Potassium Channel

Cat. No.	Product Name	Target	Research Area	Chemical Structure

HY-N6691

Veratridine 3 篇文献验证 3-Veratroylveracevine	Sodium Channel	Neurological Disease
藜芦定 Veratridine (3-Veratroylveracevine) 是一种植物神经毒素，是电压门控钠通道 (VGSCs) 激动剂。Veratridine 可抑制 Nav1.7 的峰值电流，IC₅₀ 为 18.39 μM。Veratridine 主要通过激活钠离子通道、阻止通道失活和增加钠离子内流，对钠离子通道进行调控。

HY-N0212

Peimine 3 篇文献验证 Verticine; Dihydroisoimperialine	Apoptosis Interleukin Related TNF Receptor p38 MAPK NF-κB	Inflammation/Immunology Cancer
贝母甲素 Peimine (Verticine; Dihydroisoimperialine) 是一种具有口服活性的天然产物。Peimine 具有消炎、镇痛、止咳的作用。Peimine 可用于癌症和炎症相关研究。

HY-N6691R

Veratridine (Standard)	Sodium Channel	Neurological Disease
藜芦定 (Standard) Veratridine (Standard) 是 Veratridine 的分析标准品。本产品用于研究及分析应用。Veratridine (3-Veratroylveracevine) 是一种植物神经毒素，是电压门控钠通道 (VGSCs) 激动剂。Veratridine 可抑制 Nav1.7 的峰值电流，IC₅₀ 为 18.39 μM。Veratridine 主要通过激活钠离子通道、阻止通道失活和增加钠离子内流，对钠离子通道进行调控。

HY-P5813

Cd1a β-TRTX-cd1a; β-Theraphotoxin-cd1a	Calcium Channel	Neurological Disease
Cd1a 是一种从非洲蜘蛛 Ceratogyrus darlingi 中得到的β-毒素。Cd1a 具有钙离子通道调节作用。Cd1a 抑制人钙离子通道 (Ca_v2.2)( IC₅₀2.6 μM) 和小鼠钠离子通道 (Na_v1.7)。Cd1a 可用于开发外周疼痛治疗药物的研究。

HY-N0212R

Peimine (Standard)	Apoptosis Interleukin Related TNF Receptor p38 MAPK NF-κB	Inflammation/Immunology Cancer
贝母甲素 (Standard) Peimine (Standard)是 Peimine 的分析标准品。本产品用于研究及分析应用。Peimine (Verticine; Dihydroisoimperialine) 是一种具有口服活性的天然产物。Peimine 具有消炎、镇痛、止咳的作用。Peimine 可用于癌症和炎症相关研究。

Cat. No.	Product Name

HY-L0099V

Sodium Ion Channel Library	5,440 compounds
Sodium Ion Channel Library contains about 5,440 compounds, and designed for discovery of new Nav1.7 channel blockers. Sodium voltage-gated ion channel is considered to be an important component in nociception. Therefore, selective Nav1.7 channel blockers are considered as important novel analgesics. The Sodium Ion Channel Library is rich in compounds bearing saturated backbones that can be often seen in structures of other ion-channel blockers.

Sodium Ion Channel Library

5,440 compounds

Sodium Ion Channel Library contains about 5,440 compounds, and designed for discovery of new Nav1.7 channel blockers. Sodium voltage-gated ion channel is considered to be an important component in nociception. Therefore, selective Nav1.7 channel blockers are considered as important novel analgesics. The Sodium Ion Channel Library is rich in compounds bearing saturated backbones that can be often seen in structures of other ion-channel blockers.

Cat. No.	Product Name	Target	Research Area

HY-P5813

Cd1a β-TRTX-cd1a; β-Theraphotoxin-cd1a	Calcium Channel	Neurological Disease
Cd1a 是一种从非洲蜘蛛 Ceratogyrus darlingi 中得到的β-毒素。Cd1a 具有钙离子通道调节作用。Cd1a 抑制人钙离子通道 (Ca_v2.2)( IC₅₀2.6 μM) 和小鼠钠离子通道 (Na_v1.7)。Cd1a 可用于开发外周疼痛治疗药物的研究。

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6691

Veratridine 3 篇文献验证 3-Veratroylveracevine	Alkaloids Structural Classification Veratrum nigrum Linn. Liliaceae Source classification Plants Isoquinoline Alkaloids	Sodium Channel
藜芦定 Veratridine (3-Veratroylveracevine) 是一种植物神经毒素，是电压门控钠通道 (VGSCs) 激动剂。Veratridine 可抑制 Nav1.7 的峰值电流，IC₅₀ 为 18.39 μM。Veratridine 主要通过激活钠离子通道、阻止通道失活和增加钠离子内流，对钠离子通道进行调控。

HY-N0212

Peimine 3 篇文献验证 Verticine; Dihydroisoimperialine	Alkaloids Piperidine Alkaloids Structural Classification Fritillaria thunbergii Miq. Liliaceae Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields	Apoptosis Interleukin Related TNF Receptor p38 MAPK NF-κB
贝母甲素 Peimine (Verticine; Dihydroisoimperialine) 是一种具有口服活性的天然产物。Peimine 具有消炎、镇痛、止咳的作用。Peimine 可用于癌症和炎症相关研究。

HY-N6691R

Veratridine (Standard)	Alkaloids Structural Classification Veratrum nigrum Linn. Liliaceae Source classification Plants Isoquinoline Alkaloids	Sodium Channel
藜芦定 (Standard) Veratridine (Standard) 是 Veratridine 的分析标准品。本产品用于研究及分析应用。Veratridine (3-Veratroylveracevine) 是一种植物神经毒素，是电压门控钠通道 (VGSCs) 激动剂。Veratridine 可抑制 Nav1.7 的峰值电流，IC₅₀ 为 18.39 μM。Veratridine 主要通过激活钠离子通道、阻止通道失活和增加钠离子内流，对钠离子通道进行调控。

HY-N0212R

Peimine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Fritillaria thunbergii Miq. Liliaceae Source classification Plants	Apoptosis Interleukin Related TNF Receptor p38 MAPK NF-κB
贝母甲素 (Standard) Peimine (Standard)是 Peimine 的分析标准品。本产品用于研究及分析应用。Peimine (Verticine; Dihydroisoimperialine) 是一种具有口服活性的天然产物。Peimine 具有消炎、镇痛、止咳的作用。Peimine 可用于癌症和炎症相关研究。

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