2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. Seladelpar Lysine dihydrate

Seladelpar Lysine dihydrate  (Synonyms: MBX-8025 Lysine dihydrate; RWJ-800025 Lysine dihydrate)

目录号: HY-19522C
产品使用指南 技术支持

Seladelpar (MBX-8025) Lysine dihydrate 是 Seladelpar (HY-19522) 的赖氨酸二水合物盐形式。Seladelpar Lysine dihydrate 是一种口服有效的 PPAR-δ 激动剂，EC50 为 2 nM。Seladelpar Lysine dihydrate 对 PPARδ 的选择性分别是对 PPARα 和 PPARγ 的 750 和 2500 多倍。Seladelpar Lysine dihydrate 可用于研究原发性胆汁性胆管炎。Seladelpar Lysine dihydrate 可使高血糖、高胰岛素血症、葡萄糖、血清脂质和胆固醇水平正常化，改善小鼠模型中的非酒精性脂肪性肝炎。

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Seladelpar Lysine dihydrate Chemical Structure

Seladelpar Lysine dihydrate Chemical Structure

CAS No. : 928821-40-3

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Seladelpar Lysine dihydrate 的其他形式现货产品:

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Seladelpar Lysine dihydrate 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Seladelpar (MBX-8025) Lysine dihydrate is the Lysine dihydrate salt form of Seladelpar (HY-19522). Seladelpar Lysine dihydrate is an orally active agonist for potent PPAR-δ, with EC50 of 2 nM. Seladelpar Lysine dihydrate shows more than 750-fold and 2500-fold selectivity over the PPARα and PPARγ receptors, respectively. Seladelpar Lysine dihydrate can be used for the study of primary biliary cholangitis. Seladelpar Lysine dihydrate normalizes hyperglycemia, hyperinsulinemia, glucose, serum lipids and cholesterol levels, ameliorates the nonalcoholic steatohepatitis in mouse model[1][2].

IC50 & Target

PPARδ

2 nM (EC50)

分子量

626.68

Formula

C27H41F3N2O9S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Seladelpar Lysine dihydrate 相关分类

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Seladelpar Lysine dihydrate928821-40-3MBX-8025 Lysine dihydrateRWJ-800025 Lysine dihydratePPARPeroxisome proliferator-activated receptorsinsulin resistancediabetesatherogenic dyslipidemiaonalcoholic steatohepatitisNASHInhibitorinhibitorinhibit

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