2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. SEP-363856 mesylate

SEP-363856 mesylate  (Synonyms: SEP-856 mesylate)

目录号: HY-136109E
产品使用指南

摩尔计算器

SEP-363856 (SEP-856) mesylate 是具有口服活性的 TAAR1 和 5-HT1A 激动剂、中枢神经系统活性的抗精神病活性化合物，具有研究精神分裂症的潜力。

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SEP-363856 mesylate Chemical Structure

SEP-363856 mesylate Chemical Structure

CAS No. : 2375116-27-9

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SEP-363856 mesylate 的其他形式现货产品:

Customer Review

Other Forms of SEP-363856 mesylate:

SEP-363856 mesylate 相关抗体

Top Publications Citing Use of Products

查看 5-HT Receptor 亚型特异性产品:

查看所有亚型
5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SEP-363856 (SEP-856) mesylate, an orally active TAAR1 and 5-HT1A agonist and CNS active psychotropic agent with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects. SEP-363856 mesylate has the potential for the study of schizophrenia[1].

IC50 & Target[1]

5-HT1A Receptor

2.3 μM (EC50)

5-HT1B Receptor

15.6 μM (EC50)

5-HT1D Receptor

0.262 μM (EC50)

5-HT2A Receptor

>10 μM (EC50)

5-HT2C Receptor

30 μM (EC50)

5-HT7 Receptor

6.7 μM (EC50)

TAAR1

0.14 μM (EC50)

体外研究
(In Vitro)

SEP-856 (10 μM) mesylate 对 α2A、α2B、D2、5-HT1A、5-HT1B、5-HT1D、5-HT2A、5-HT2B、5-HT2C 和 5-HT7 受体的特异性结合抑制率 >50%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SEP-363856 mesylate 相关抗体:
体内研究
(In Vivo)

SEP-856 (0.3、1 和 10 mg/kg，腹腔注射) mesylate 具有中枢神经活性，表现出与已知抗精神病化合物相似的行为特征[1]。
SEP-856 (0.3、1 和 10 mg/kg，口服一次) mesylate 可显著降低 PCP 引起的多动症[1]。
口服 SEP-856 mesylate (1、3 和 10 mg/kg) 会导致 REM 睡眠出现剂量依赖性减少、REM 睡眠潜伏期增加以及累积觉醒 (W) 时间增加[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

279.38

Formula

C10H17NO4S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SEP-363856 mesylate 相关分类

  • 摩尔计算器

  • 稀释计算器

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SEP-3638562375116-27-9SEP-856SEP363856SEP 363856SEP856SEP 8565-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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