2. Anti-infection
  3. Antibiotic Bacterial SARS-CoV
  4. Setomimycin

Setomimycin 是一种有效的抗生素。Setomimycin 抑制 SARS-CoV-2 Mpro 酶，IC50 值为 12.02 µM。Setomimycin 具有抗炎和抗氧化特性。Setomimycin 具有抗增殖和抗肿瘤活性。

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Setomimycin Chemical Structure

Setomimycin Chemical Structure

CAS No. : 69431-87-4

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Setomimycin 相关抗体

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Setomimycin is a potent antibiotic. Setomimycin inhibits the SARS-CoV-2 Mpro enzyme with an IC50 value of 12.02 µM. Setomimycin shows anti-inflammatory and antioxidant properties. Setomimycin shows antiproliferative and antitumor activity[1][2].

IC50 & Target

IC50: 12.02 µM (SARS-CoV-2 Mpro)[1]
体外研究
(In Vitro)

Setomimycin (0.01-1 µM) 以剂量依赖性方式抑制细胞因子 IL-1β、IL-6 和 TNF-α 的释放以及一氧化氮的释放在 LPS 刺激的 RAW 264.7 细胞中[1]。
Setomimycin (compound 1) 显示出抗菌活性，对 Staphylococcus aureus, Bacillus cereus, Bacillus subtilis, Micrococcus luteus 的 MIC 分别为 8、4、16、4 μg/mL [2].
Setomimycin (0-100 µM；5 天) 显示出抗增殖活性并抑制集落形成[2]。
Setomimycin (4, 5.5, 7 µM) 降低 p-MEK、p-ERK、Bcl-2 的蛋白表达，增加 Par-4 的表达[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Setomimycin 相关抗体:

Cell Proliferation Assay[2]

Cell Line: A549; HOP-92; Panc-1; MiaPaca-2 cells
Concentration: 0-100 µM
Incubation Time: 44 h
Result: Showed antiproliferative activity with IC50s of 11.45, >100, 48, 4.57 µM for A549; HOP-92; Panc-1; MiaPaca-2 cells, respectively.

Western Blot Analysis[2]

Cell Line: MCF-7, HCT-116 cells
Concentration: 4, 5.5, 7 µM
Incubation Time:
Result: Decreased the protein expression of p-MEK, p-ERK, Bcl-2, increased the expression of Par-4 in a dose-dependent manner.
体内研究
(In Vivo)

Setomimycin (20 mg/kg；i.p.；隔天给药两周) 在小鼠体内显示出抗肿瘤活性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6 weeks, 25-30 g, female BALB/c mice (4T1 cells)[2]
Dosage: 20 mg/kg
Administration: I.p.; every other day for two weeks
Result: Decreased primary tumor weight (76%) and volume (90.5%).
分子量

580.58

Formula

C34H28O9
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Setomimycin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Setomimycin69431-87-4AntibioticBacterialSARS-CoVSARS coronavirusanti-inflammatoryantioxidantantiproliferativeantitumor4T1 cellsInhibitorinhibitorinhibit

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HY-124439
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