2. Inhibitory Antibodies
  3. Setrusumab

Setrusumab  (Synonyms: BPS 804)

目录号: HY-P99398 纯度: 99.00%
COA 技术支持

Setrusumab (BPS 804) 是一种靶向硬化蛋白 (sclerostin) 的完全人源单克隆抗体。Setrusumab 有效改善骨强度。Setrusumab 可用于成骨不全症 (OI) 和癌症的研究。

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CAS No. : 1847394-95-9

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规格 价格 是否有货 数量
1 mg ￥3000
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5 mg ￥9500
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Setrusumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Setrusumab (BPS 804) is a fully human monoclonal antibody targets sclerostin. Setrusumab efftively improves bone strength. Setrusumab can be used for the resesrch of Osteogenesis Imperfecta (OI) and cancer[1].

同型

Human IgG2
种属

Human
体内研究
(In Vivo)

Setrusumab (100 mg/kg；每周一次，静脉注射，持续 4 周) 抑制小鼠乳腺癌诱导的骨转移和肌肉无力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8-week-old female immune-compromised CB-17/lcr-Prkdcscid/Rj mice with MDA-MB-231 breast cancer cells injection[1]
Dosage: 100 mg/kg
Administration: Intravenous injection; 100 mg/kg once a week for 4 weeks
Result: Significantly inhibited tumor growth in bones and breast cancer cell dissemination into other organs. Inhibited breast cancer-induced osteolytic lesions and subsequent loss of bone mass of the distal femur and of the proximal tibia. Redued phosphorylation of IKKα, IKKβ, and p65.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG2 lambda
Biological Activity
  • Loaded Setrusumab on AHC2 biosensor, can bind SOST Protein, Human (Biotinylated, HEK293, His-Avi, HY-P78209) with an affinity constant of 8.123E-11 M as determined in BLI assay.
纯度 & 产品资料

纯度: 99.00%

COA (264 KB) SDS-PAGE (67 KB) SEC-HPLC (99 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Setrusumab 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Setrusumab1847394-95-9BPS 804BPS804BPS-804Othersmonoclonal antibodyOIcancerbone metastasemuscle weaknessInhibitorinhibitorinhibit

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