2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. SEW84

SEW84 是 Aha1 刺激的 Hsp90 (ASH) ATP 酶活性的抑制剂。SEW84 抑制 Aha1 刺激的 Hsp90 (ASH) 活性，IC50 值为 0.3 μM。SEW84 可用于蛋白质沉积疾病的研究。

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SEW84 Chemical Structure

SEW84 Chemical Structure

CAS No. : 259089-67-3

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SEW84 相关抗体

Top Publications Citing Use of Products

查看 HSP 亚型特异性产品:

查看所有亚型
HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

IC50 & Target

IC50: 0.3 μM (ASH); 1.3 μM (GR-dependent luciferase expression); 0.7 μM (AR-dependent luciferase expression)[1]
体外研究
(In Vitro)

SEW84 (5 μM) shows complete inhibition of ASH activity with an IC50 value of 0.3 μM[1].
SEW84 inhibited the GR- and AR-dependent luciferase expression with IC50 values of 1.3 and 0.7 μM, respectively[1].
SEW84 (0-20 μM) inhibits the Hsp90-Dependent folding of firefly luciferase[1].
SEW84 (0, 3, 10, 30 μM; 24 h) specifically clears phosphorylated tau[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SEW84 相关抗体:

Western Blot Analysis[1]

Cell Line: tau-0N4R-HeLa cells
Concentration: 0, 3, 10, 30 μM
Incubation Time: 24 h
Result: Reduced the expression of phospho-Tau.

Immunofluorescence[1]

Cell Line: RFP-tau-0N4R HEK cells
Concentration: 1, 10 μM
Incubation Time: 24 h
Result: Completely abrogated the aggregation of tau.

Cell Proliferation Assay[1]

Cell Line: LNCaP and 22Rv1 cells
Concentration: 0-100 μM
Incubation Time: 24 h
Result: Observed a synergistic decrease in LNcaP cell proliferation when combined 1 μM GA with 10 μM SEw84.
分子量

422.40

Formula

C19H14F4N4OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SEW84 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SEW84259089-67-3SEW04784SEW 84SEW-84SEW 04784SEW-04784HSPHeat shock proteinsAha1stimulated Hsp90 (ASH)ATPaseproteostatic diseaseInhibitorinhibitorinhibit

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产品名称：
SEW84
目录号：
HY-152184
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