2. Metabolic Enzyme/Protease
  3. Dipeptidyl Peptidase
  4. SGP8

SGP8 (IAVPGEVA) 是一种大豆 11 S 球蛋白水解产生的八肽，具有调节脂质代谢、炎症和纤维化的作用。SGP8 (IAVPGEVA) 对 DPP4 表现抑制活性并抑制 JNK-c-Jun 信号通路，有抑制非酒精性脂肪性肝炎 (NASH) 的能力。

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SGP8 Chemical Structure

SGP8 Chemical Structure

CAS No. : 855790-98-6

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SGP8 相关抗体

Top Publications Citing Use of Products

查看 Dipeptidyl Peptidase 亚型特异性产品:

查看所有亚型
DPP-1 DPP-2 DPP-4 DPP-8 DPP-9

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SGP8 (IAVPGEVA) is an octapeptide produced by hydrolysis of soybean 11S globulin, which has the effects of regulating lipid metabolism, inflammation and fibrosis. SGP8 (IAVPGEVA) exhibits inhibitory activity against DPP4 and inhibits the JNK-c-Jun signaling pathway, and has the ability to inhibit non-alcoholic steatohepatitis (NASH)[1].

IC50 & Target[1]

DPP-4

 

体外研究
(In Vitro)

SGP8 (0,100 和 500 µM; 24 h) 对脂质代谢，炎症和纤维化具有调节作用[1]。
SGP8 (0,100 和 500 µM; 24 h) 显著提高了体内血清 GLP-1 含量， SGP8 对 DPP4 具有抑制活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SGP8 相关抗体:

Real Time qPCR[1]

Cell Line: L02 cells
Concentration: 0,100 and 500 µM
Incubation Time: 24h
Result: Improved the mRNA expression of lipid metabolism genes related to Cd36, Scd1, Cpt1 and Pparα and significantly reduced the mRNA expression of inflammatory genes Tnfα, Il-1β, and Ccl5.

Western Blot Analysis[1]

Cell Line: L02 cells
Concentration: 0,100 and 500 µM
Incubation Time: 24h
Result: Reduced the expression of lipid metabolism genes related to CD36, FAS, and SREBP-1 compared to the 1 mM PO model group.

Immunofluorescence[1]

Cell Line: LX2 cells
Concentration: 0 and 500 µM
Incubation Time: 24h
Result: Reduced effectively TGFβ1-induced expression of α-SMA and Collagen I protein expression.
体内研究
(In Vivo)

SGP8 (15 mg/kg，每天腹腔注射 1 次持续4周) 减轻 MCD 饮食引起的小鼠脂肪性肝炎[1]。
SGP8 (15 mg/kg，每天腹腔注射 1 次持续8周) 减轻 HFD 引起的小鼠肝损伤和代谢紊乱[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Healthy 7-week-old male C57BL/6J mice (22 and 27 g)[1]
Dosage: 15 mg/kg; everydays for four weeks
Administration: i.g.
Result: Did not reverse the weight loss of mice caused by the MCD diet. Reduces the ratio of liver weight to body weight, as well as liver TG and TC content. Reduces the activities of ALT and AST in the serum of MCD dietinduced NASH mice. Improved liver fibrosis in MCD diet-induced NASH mice.
分子量

754.87

Formula

C34H58N8O11
CAS 号
Sequence

Ile-Ala-Val-Pro-Gly-Glu-Val-Ala
Sequence Shortening

IAVPGEVA
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SGP8 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SGP8855790-98-6SGP 8SGP-8Dipeptidyl PeptidaseDPPNonalcoholic steatohepatitis (NASH)JNK-c-Jun pathwayDPP4L02 and LX2 cellsInhibitorinhibitorinhibit

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目录号：
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