2. Protein Tyrosine Kinase/RTK Apoptosis
  3. Src Apoptosis
  4. SI-2

SI-2 (EPH 116) 是类固醇受体辅激活剂 3 (SRC-3) 的抑制剂，可降低细胞中 SRC-3 的转录活性和蛋白质水平，对癌细胞具有细胞毒性，IC50 范围为 3-20 nM，可抑制 MDA-MB-468 的迁移，诱导 MDA-MB-468 细胞凋亡 (apoptosis)。SI-2 可抑制小鼠模型中的肿瘤生长，且对心脏和其他主要器官无明显毒性（20 mg/kg）。

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SI-2 Chemical Structure

SI-2 Chemical Structure

CAS No. : 223788-33-8

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SI-2 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SI-2 (EPH 116) is an inhibitor for steroid receptor coactivator-3 (SRC-3), which reduces the transcriptional activity and protein concentration of SRC-3 in cells, exhibits cytotoxicity in cancer cell, with IC50s ranging from 3-20 nM, inhibits migration of MDA-MB-468, induces apoptosis of MDA-MB-468. SI-2 inhibits the tumor growth in mouse models, without significant toxicity for heart and other major organs (20 mg/kg)[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
TOV112D EC50
0.004 μM
Compound: C9
Growth inhibition of human TOV112D cells harbouring p53 R175H mutant incubated for 3 days by MTS assay
Growth inhibition of human TOV112D cells harbouring p53 R175H mutant incubated for 3 days by MTS assay
[PMID: 33538587]
分子量

265.31

Formula

C15H15N5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SI-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SI-2223788-33-8EPH 116SI2SI 2EPH116EPH-116SrcApoptosisMDA-MB-468MCF-7T47DBT-474HeLaHEK293CD-1 mouseInhibitorinhibitorinhibit

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