2. Immunology/Inflammation
  3. Salt-inducible Kinase (SIK)
  4. SIKs-IN-1

SIKs-IN-1 (compound 8h) 是一种盐诱导激酶 (SIKs) 抑制剂，是一种嘧啶-5-羧酰胺衍生物。SIKs 调节 M1/M2 巨噬细胞的转化，参与炎症过程。SIKs-IN-1 抑制 SIK 活性，上调抗炎细胞因子 IL-10，下调促炎细胞因子 IL-12。SIKs-IN-1 在 DSS 诱导的结肠炎模型中显示出良好的抗炎作用。

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SIKs-IN-1 Chemical Structure

SIKs-IN-1 Chemical Structure

CAS No. : 2927557-06-8

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SIKs-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Salt-inducible Kinase (SIK) 亚型特异性产品:

查看所有亚型
SIK1 SIK2 SIK3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, is a Salt-inducible kinases (SIKs) inhibitor. SIKs regulates the transformation of M1/M2 macrophages, involving in inflammation process. SIKs-IN-1 inhibits SIK activity, up-regulates anti-inflammatory cytokine IL-10, but down-regulates pro-inflammatory cytokine IL-12. SIKs-IN-1 shows excellent anti-inflammatory effects in a DSS-induced colitis model[1].

分子量

507.58

Formula

C27H31F2N7O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SIKs-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SIKs-IN-12927557-06-8Salt-inducible Kinase (SIK)Inhibitorinhibitorinhibit

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产品名称：
SIKs-IN-1
目录号：
HY-149365
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