2. Cell Cycle/DNA Damage Epigenetics
  3. Sirtuin
  4. SIRT1/2/3-IN-1

SIRT1/2/3-IN-1 (compound 10) 是一种高效的，选择性的和细胞渗性的 SIRT1/2/3 抑制剂，抑制 SIRT1，SIRT2 和 SIRT3 的 IC50 值分别为 0.54，0.253，0.72 μM。SIRT1/2/3-IN-1 (compound 10) 可用于癌症研究。

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SIRT1/2/3-IN-1 Chemical Structure

SIRT1/2/3-IN-1 Chemical Structure

CAS No. : 2413212-06-1

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SIRT1/2/3-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Sirtuin 亚型特异性产品:

查看所有亚型
Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SIRT1/2/3-IN-1 (compound 10) is a highly potent, selective and cell permeable inhibitor of SIRT1, SIRT2 and SIRT3 with IC50s of 0.54, 0.253, and 0.72 μM, respectively. SIRT1/2/3-IN-1 (compound 10) can be used for research of cancer[1].

IC50 & Target

IC50: 0.54 μM (SIRT1), 0.253 μM (SIRT2), and 0.72 μM (SIRT3)[1]
体外研究
(In Vitro)

SIRT1/2/3-IN-1 (compound 10) possesses cell growth inhibition to cancer cells with time- and concentration-dependently[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SIRT1/2/3-IN-1 相关抗体:

Western Blot Analysis[1]

Cell Line: HCT116 human colon cancer cells
Concentration: 0, 0.5, 2, 10, 50, and 100 µM
Incubation Time: 8 h
Result: Inhibited deacetylation of the K382-acetylated tumor suppresser protein p53.

Cell Proliferation Assay[1]

Cell Line: Human MCF-7 breast cancer cells and human SK-MEL-2 melanoma cells
Concentration: 0, 5, 12.5, 25, 50 or 100 µM
Incubation Time: 24 h, 48 h or 72 h
Result: Concentration-dependently inhibited cell growth.
分子量

934.18

Formula

C46H63N9O8S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SIRT1/2/3-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SIRT1/2/3-IN-12413212-06-1Sirtuinbicyclic analogSK-MEL-2 melanoma cellsdeacylationcyclic peptideInhibitorinhibitorinhibit

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