2. Cell Cycle/DNA Damage Epigenetics
  3. Sirtuin
  4. SIRT2-IN-10

SIRT2-IN-10 (Compound 12) 是一种有效的 SIRT2 抑制剂，IC50 为 1.3 μM。SIRT2-IN-10 可用于癌症和神经退行性疾病的研究。

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SIRT2-IN-10 Chemical Structure

SIRT2-IN-10 Chemical Structure

CAS No. : 296793-09-4

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SIRT2-IN-10 相关抗体

Top Publications Citing Use of Products

查看 Sirtuin 亚型特异性产品:

查看所有亚型
Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SIRT2-IN-10 (Compound 12) is a potent SIRT2 inhibitor with an IC50 of 1.3 μM. SIRT2-IN-10 can be used for the research of cancer and neurodegenerative disease[1].

IC50 & Target

SIRT2[1]
体外研究
(In Vitro)

SIRT2-IN-10 (Compound 12) (0-50 μM; 72 h) inhibits the proliferation of MCF-7 cells in a concentration-dependent manner[1].
SIRT2-IN-10 (6.25-50 μM; 6 h) increased the acetylation level of α-tubulin in a concentration-dependent manner in MCF-7 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SIRT2-IN-10 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MCF-7 cells
Concentration: 0, 0.6, 1.8, 5.5, 16.6 and 50.0 μM
Incubation Time: 72 h
Result: Inhibited the proliferation in a concentration-dependent manner.

Western Blot Analysis[1]

Cell Line: MCF-7 cells
Concentration: 6.25, 12.5, 25 and 50 μM
Incubation Time: 6 h
Result: Dose-dependently increased the acetylation level of α-tubulin.
分子量

475.56

Formula

C28H21N5OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SIRT2-IN-10 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SIRT2-IN-10296793-09-4Sirtuincancerneurodegenerative diseaseMCF-7Inhibitorinhibitorinhibit

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目录号：
HY-151522
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