2. Cell Cycle/DNA Damage Epigenetics
  3. Sirtuin
  4. SIRT3 activator 2

SIRT3 activator 2 (compound 2a) 是 SIRT3 激活剂。SIRT3 activator 2 在 SH-SY5Y 中通过热稳定性推测可直接与 SIRT3 结合，通过 SIRT3 依赖性清除 α-Syn。SIRT3 activator 2 改善帕金森小鼠的运动功能，剂量依赖性阻止黑质 DA 神经元丢失。

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SIRT3 activator 2 Chemical Structure

SIRT3 activator 2 Chemical Structure

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SIRT3 activator 2 相关抗体

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Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SIRT3 activator 2 (compound 2a) is a SIRT3 activator. SIRT3 activator 2 improved the thermal stability of SIRT3 in SH-SY5Y cells, indicating that it can directly bind to SIRT3, has SIRT3 dependency in SH-SY5Y to clear α-Syn. SIRT3 activator 2 improves motor function in Parkinson mice, preventing Parkinson (DA) neuron loss in the substantia nigra in a dose-dependent manner[1].

IC50 & Target

SIRT3

 

体外研究
(In Vitro)

SIRT3 activator 2 (compound 2)(10 μM, 100 μM) 是 SIRT3 激活剂[1]。
SIRT3 activator 2 (10 μM; 24h) 提高了 SH-SY5Y 细胞中 SIRT3 的热稳定性 (CETSA)，表明可直接与 SIRT3 结合 (wb)[1]。
SIRT3 activator2 (10 μM; 24h) 在 SH-SY5Y 细胞中通过 SIRT3 依赖性，消除 α-Syn (wb) 来保护神经元[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SIRT3 activator 2 相关抗体:

Western Blot Analysis[1]

Cell Line: SH-SY5Y
Concentration: 10 μM
Incubation Time: 24 h
Result: Improved the thermal stability (CETSA) of SIRT3 in SH-SY5Y cells and could bind directly to SIRT3.

Apoptosis Analysis[1]

Cell Line: Ttransfected with SIRT3 siRNAs in SH-SY5Y cells.
Concentration: 10 μM
Incubation Time: 24 h
Result: Showed that the protective effect of SIRT3 activator 2 on MPP+ (600 μM) or 6-OHDA(100μM)-induced neuronal injury disappeared and the expression level of α-Syn did not change significantly after SIRT3 silences.
体内研究
(In Vivo)

SIRT3 activator 2 (10，20，40 mg/kg; Intravenous injection (i.v.); 每次一次; 24 天) 改善过表达 α-突触核蛋白诱导的帕金森小鼠的运动功能[1]。
SIRT3 activator 2 (10，20，40 mg/kg; 脑部微量注射) 剂量依赖性阻止过表达 α-突触核蛋白诱导的黑质 DA 神经元丢失 (免疫组化)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Parkinson mouse model injected with overexpression of A53T α-synuclein[1]
Dosage: 10, 20, 40 mg/kg
Administration: Intravenous injection (i.v.)；Once daily; 24 days;The viruses (2.5 x 1012 genomic particles/ml) were infused to the right substantia nigra of mouse
Result: Showed that the movement function of mice was improved by increasing the walking distance, decreasing the descending time on the rod and increasing the descending time on the rotating rod.
分子量

492.50

Formula

C22H24N2O9S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SIRT3 activator 2 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SIRT3 activator 2Sirtuinα-SynDAParkinsonInhibitorinhibitorinhibit

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